Evidence map›Paper›PMID 31719801›Full record

ReviewReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Cardiotoxicity of mediastinal radiotherapy.

Ivica Ratosa, Maja Ivanetic Pantar

Open access · diamondAbstract readReview
In one paragraph

Review in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

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  15. Life after acute pandysautonomia: a 40-year journey.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ivica RatosaDivision of Radiation Oncology, Institute of Oncology, Zaloska cesta 2, 1000 Ljubljana, Slovenia.
Maja Ivanetic PantarDivision of Radiation Oncology, Institute of Oncology, Zaloska cesta 2, 1000 Ljubljana, Slovenia.
Institute of Oncology Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore available recent literature related to cardiotoxicity following mediastinal radiation.

backgroundRadiotherapy-related heart injury is well documented, with no apparent safety threshold dose. The number of long-term cancer survivors exposed to mediastinal radiotherapy at some point of their treatment is increasing. Heart dosimetric parameters are of great importance in developing a treatment plan, but few data are available regarding radiosensitivity and dose-volume constraints for specific heart structures. MATERIALS AND

methodsIn October 2018, we identified articles published after 1990 through a PubMed/MEDLINE database search. The authors examined rough search results and manuscripts not relevant for the topic were excluded. We extracted clinical outcomes following mediastinal radiotherapy of childhood cancers, lymphoma, medulloblastoma, thymic cancers and hematopoietic cell transplantation survivors and evaluated treatment planning data, whenever available.

resultsA total of 1311 manuscripts were identified in our first-round search. Of these manuscripts, only 115 articles, matching our selection criteria, were included.

conclusionsStudies uniformly show a linear radiation dose-response relationship between mean absorbed dose to the heart (heart-D

Indexed as

2D-RT, two-dimensional radiotherapy3D-CRT, three-dimensional conformal radiation therapyCardiotoxicityCI, confidence intervalCSI, craniospinal irradiationCVD, Cardiovascular diseaseDmax, maximum absorbed dose in a specified volumeDmean, mean absorbed radiation dose in a specified volumeDose-volume predictorsEQD2, equivalent dose in 2 Gy fractionsG, gradeGy, GrayHR, hazard ratioHT, Helical tomotherapyIFRT, involved field radiotherapyIMRT, intensity modulated radiation therapyINRT, involved node radiotherapyISRT, involved site radiotherapyLAD, left anterior descending arteryMediastinal radiotherapyMediastinal tumoursMv, megavoltageNormal tissue complication probabilityNTCP, normal tissue complication probabilityOAR, organs at riskOR, odds ratioPTV, planning target volumeRR, relative risksTBI, total body irradiationVMAT, volumetric modulated arc therapyVx, receiving at last x Gy

Identifiers

PMID31719801
PMCPMC6838493
OpenAlexW2982332017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.