ReviewNature reviews. Endocrinology2020
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.
Review in Nature reviews. Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 371 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
371 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Frontiers in endocrinology · 2026Pooled it
- Environmental endocrine disruptors and endometrial cancer: a systematic review of epidemiological studies.Frontiers in endocrinology · 2026Pooled it
- Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects.Archives of toxicology · 2026Pooled it
- A systematic review of exposure to endocrine disruptors and energy expenditure in mice.Environmental health : a global access science source · 2025Pooled it
- Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations.Toxicological sciences : an official journal of the Society of Toxicology · 2024Pooled it
- Review
- Article
- Screening of Estrogenic and Antiestrogenic Effects of Estradiol, Bisphenol A, and Fulvestrant Using 2D and 3D Breast Cancer Cell Systems With a Luciferase Reporter Gene Assay.Journal of applied toxicology : JAT · 2026Article
- The NorthMom study: population-based follow-up of women in a birth cohort to assess pregnancy exposures and effects on breast cancer risk factors.BMC public health · 2026Observational
- Prenatal and childhood exposure to common plasticizers and risk-taking behavior in young adolescents.Environmental research · 2026Article
- Development of a new dispersive liquid-liquid microextraction/UPLC method for determining bisphenols and estrogens in water based on FeAnalytical and bioanalytical chemistry · 2026Article
- Epigenetic regulation of ovarian steroidogenesis in PCOS: HDAC inhibitors and short-chain fatty acids.Molecular biology reports · 2026Review
- Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026Observational
- Joint associations between gestational environmental chemical mixtures and child behavioral outcomes.Environment international · 2026Article
- Contribution of Consumer Products to Emerging Chemical Exposures in a Preconception Cohort Study.Environmental science & technology · 2026Article
- Bisphenol A and cancer: a critical review of the epidemiologic literature with an emphasis on exposure assessment.Environmental health : a global access science source · 2026Review
- Molecular characterization of the uterotrophic assay: temporal gene expression changes in uterus and pituitary gland following ethinylestradiol.Archives of toxicology · 2026Article
- SynergisticiScience · 2026Article
- Thermodynamic and Structural Insights into Endocrine Disruptor Adsorption.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Endocrine Disruptors and Gynecological Malignancies.Diagnostics (Basel, Switzerland) · 2026Review
311 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.