ArticleMucosal immunology2020
Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury.
Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Prevalence of bovine endometritis, virulence mechanisms ofVirulence · 2026Pooled it
- Multidrug-resistant avian pathogenicVeterinary and animal science · 2026Article
- IL-17B protects against uropathogenicMicrobiology spectrum · 2026Article
- Research Progress on perinatalFrontiers in microbiology · 2026Review
- Case Report: Uremia secondary to acute pyelonephritis in a patient with type 2 diabetes mellitus.Frontiers in medicine · 2026Article
- Reply to Possenriede et al.: LDLR as a targetable HlyA receptor inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dissecting the High Esterase/Lipase Activity and Probiotic Traits inFoods (Basel, Switzerland) · 2025Article
- LDL receptor-mediated endocytosis ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The brain-body circuit mediates acute stress-induced antiinflammatory reflex in bacterial cystitis by suppressing ILC2 activation.JCI insight · 2025Article
- Antibacterial impact of biosynthesized zinc oxide nanoparticles on uropathogenic Escherichia coli and in vivo assessment of physiological and histological alterations.Scientific reports · 2025Article
- Role for RTX-family toxin HlyA of extraintestinal pathogenicFEMS microbes · 2025Article
- Article
- Influence of Urinary Urea Concentration on Hemolytic Activity and Cytotoxicity of Uropathogenic Morganella morganii Strain.Bulletin of experimental biology and medicine · 2024Article
- Genotypic and phenotypic characterisation of asymptomatic bacteriuria (ABU) isolates displaying bacterial interference against multi-drug resistant uropathogenic E. Coli.Archives of microbiology · 2024Article
- Deletion of Sphingosine Kinase 2 Attenuates Acute Kidney Injury in Mice with Hemolytic-Uremic Syndrome.International journal of molecular sciences · 2024Article
- Progress toward a vaccine for extraintestinal pathogenicInfection and immunity · 2024Article
- Correlation between antimicrobial resistance, biofilm formation, and virulence determinants in uropathogenic Escherichia coli from Egyptian hospital.Annals of clinical microbiology and antimicrobials · 2024Article
- Features of Hemolysin Biosynthesis by Morganella morganii.Bulletin of experimental biology and medicine · 2023Article
- Resistance and Virulence Surveillance inMicroorganisms · 2023Article
- Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs), inducing acute pyelonephritis and may result in permanent renal scarring and failure. Alpha-hemolysin (HlyA), a key UPEC toxin, causes serious tissue damage; however, the mechanism through which HlyA induces kidney injury remains unclear. In the present study, granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by renal epithelial cells was upregulated by HlyA in vitro and in vivo, which induced M1 macrophage accumulation in kidney, and ADAM10 was found involved in HlyA-induced GM-CSF. Macrophage elimination or GM-CSF neutralization protected against acute kidney injury in mice, and increased GM-CSF was detected in urine of patients infected by hlyA-positive UPEC. In addition, HlyA was found to promote UPEC invasion into renal epithelial cells by interacting with Nectin-2 in vitro. However, HlyA did not affect bacterial titers during acute kidney infections, and HlyA-induced invasion did not contribute to GM-CSF upregulation in vitro, which indicate that HlyA-induced GM-CSF is independent of bacteria invasion. The role of GM-CSF in HlyA-mediated kidney injury may lead to novel strategies to treat acute pyelonephritis.
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