ArticleNature communications2019
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 7 of them syntheses that pooled it.
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52citing papers in PubMed, 7 pooled it
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Who cites it
52 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.Atherosclerosis · 2026Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.Journal of the American Heart Association · 2024Pooled it
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review.Frontiers in nutrition · 2023Pooled it
- Kernel-based gene-environment interaction tests for rare variants with multiple quantitative phenotypes.PloS one · 2022Pooled it
- Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions.European journal of human genetics : EJHG · 2021Pooled it
- Natural products targeting cytokine-regulated SASP inflammation networks in Ovarian cancer: Implications on immune escape and molecular resistance.Inflammopharmacology · 2026Review
- Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis.Nature communications · 2026Article
- Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.Communications medicine · 2025Article
- Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Alzheimer's research & therapy · 2025Article
- Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.GeroScience · 2025Article
- Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank.Sleep health · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes.Clinical and experimental medicine · 2024Article
- Multipartite network analysis to identify environmental and genetic associations of metabolic syndrome in the Korean population.Scientific reports · 2024Article
- A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.The Journal of nutrition · 2024Article
- The clinical relevance of a polygenic risk score for type 2 diabetes mellitus in the Korean population.Scientific reports · 2024Article
- Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2024Article
Corrections and comments
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Authors and funding
148 authors.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. r.noordam@lumc.nl.
Maxime M BosDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Heming WangDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1486-7495
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0827-9101
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0193-4134
Brian E CadeDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Alisa ManningClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0247-902X
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7554-6783
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Melissa RichardBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0129-9860
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Traci M BartzCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Lisa de las FuentesDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-4689-325X
Mary FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Andrea R HorimotoLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Marjan IlkovIcelandic Heart Association, Kopavogur, Iceland.
Minjung KhoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Aldi KrajaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Changwei LiEpidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA.
Elise LimDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Yongmei LiuPublic Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Salman M TajuddinHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Ashley van der SpekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7136-0159
Zhe WangHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8046-4969
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6916-2014
Vincent LavilleCentre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0003-4946-698X
Maris AlverEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5488-2999
Maria E GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Meian HeDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-2096-921X
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Pedro Marques-VidalMedicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4548-8500
Ilja M NolteUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Lisa R YanekDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Correa AdolfoJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-9501-600X
Christie BallantyneSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.
Larry BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Nienke R BiermaszDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Niki DimouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.ORCID http://orcid.org/0000-0003-1678-9328
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Chuan GaoMolecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Medicine, University of Washington, Seattle, WA, USA.
Daniel J GottliebDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
José Haba-RubioMedicine, Sleep Laboratory, Lausanne University Hospital, Lausanne, Switzerland.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Sami HeikkinenInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Raphaël HeinzerMedicine, Sleep Laboratory, Lausanne University Hospital, Lausanne, Switzerland.
James E HixsonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-5464-1792
Jiwon LeeDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4079-7494
Jingmin LiuFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0001-6013
Kurt K LohmanPublic Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Annemarie I LuikDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lisa W MartinCardiology, School of Medicine and Health Sciences, George Washington University, Washington, D.C., USA.ORCID http://orcid.org/0000-0003-4352-0914
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3718-796X
Yuri MilaneschiCardiology, School of Medicine and Health Sciences, George Washington University, Washington, D.C., USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Jeff O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Patricia PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Alex P ReinerFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Patrick C N RensenDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-8455-4988
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Till RoennebergInstitute of Medical Psychology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
Jerome I RotterGenomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CC, USA.ORCID http://orcid.org/0000-0001-7191-1723
Pamela J SchreinerDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
James ShikanyDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephen S SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, USA.
Tamar SoferDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8520-8860
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Morris A SwertzUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Kent D TaylorGenomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CC, USA.ORCID http://orcid.org/0000-0002-2756-4370
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Robert B WallanceDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Ko Willems van DijkDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2172-7394
Caizheng YuDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Diane M BeckerDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Paul ElliottDepartment of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-7511-5684
Tõnu EskoEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0003-1982-6569
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Hans J GrabeDepartment Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Timo A LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Peter VollenweiderMedicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Tangchun WuDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yong-Bing XiangSKLORG & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Donna K ArnettDean's Office, University of Kentucky College of Public Health, Lexington, KS, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-0048-491X
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Sharon KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tanika N KellyEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Stephen B KritchevskySticht Center for Healthy Aging and Rehabilitation, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil.
Mike ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Bruce M PsatyCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA.
Charles RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Xiaofeng ZhuDepartment of Population Quantitative and Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0273-7965
Myriam FornageBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ervin F FoxCardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Xiuqing GuoGenomic Outcomes, Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CC, USA.
W James GaudermanBiostatistics, Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Charles KooperbergFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-4176-2947
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Susan RedlineDivision of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. sredline@bwh.harvard.edu.
Funding
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIMBERLY D SIEGMUND · 2016 to 2026
$25.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MShanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9MLeveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6MDiverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5MMedical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/R023484/1NCI NIH HHS P01 CA196569NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NHGRI NIH HHS U01 HG007417NHLBI NIH HHS K01 HL135405NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NHLBI NIH HHS R35 HL135818NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK117445NIH HHS S10 OD020069NIMHD NIH HHS R01 MD012765
Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
Indexed as
Genetic LociPhylogenyAdolescentAdultAgedAged, 80 and overChromosome MappingFemaleHumansLipidsMaleMiddle AgedPolymorphism, Single NucleotideSleepYoung AdultLipids
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