Evidence map›Paper›PMID 31719514›Full record

ArticleThe American journal of case reports2019

A Case of Thymic Carcinoma with Bone and Cerebral Metastases Treated with Stereotactic Radiosurgery and Chemotherapy.

Jacqueline Kropf, Giselle Castaneira, Lily T Luc, Chukwuemeka Oriala, Zachary Field, Alex Rico, Steve J Carlan

Open access · hybridAbstract readCase Reports
In one paragraph

Article in The American journal of case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Inoperable CASTLE of the thyroid gland treated with radical radiotherapy with complete remission.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jacqueline KropfDepartment of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
Giselle CastaneiraDepartment of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
Lily T LucDepartment of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
Chukwuemeka OrialaDepartment of Pathology, Orlando Regional Healthcare, Orlando, FL, USA.
Zachary FieldDepartment of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
Alex RicoDepartment of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
Steve J CarlanDivision of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USA.
Regional Health · USOrlando Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Thymic carcinoma is a rare malignant neoplasm. High-grade thymic carcinoma has a high recurrence rate following surgery, and a low 5-year survival rate. Approximately 30% of patients with thymic carcinoma will be asymptomatic at the time of diagnosis. Extrathoracic metastasis on presentation is uncommon. Treatment of the primary tumor includes surgery, chemotherapy, and fractionated radiation. A rare case of thymic carcinoma that presented with bone and cerebral metastases is reported in a patient who responded well to stereotactic radiosurgery and chemotherapy. CASE REPORT A 63-year-old woman presented to the hospital for evaluation of hip pain. She was diagnosed with a lytic bone lesion of the right femur and brain metastasis. Biopsies from the mediastinal mass and right femur showed histological features consistent with carcinoma. Immunohistochemistry showed positive immunostaining of the tumor cells for the c-kit receptor (CD117) and CD5, supporting a diagnosis of stage IVb thymic carcinoma. Treatment included stereotactic radiosurgery, which delivered multiple radiation beams to the tumor tissue from different directions to target the tumor without affecting normal tissues. She was treated as an outpatient with carboplatin and taxol after stereotactic radiosurgery. The patient recovered well following treatment. CONCLUSIONS A case of thymic carcinoma with bone and cerebral metastases was successfully treated with stereotactic radiosurgery and chemotherapy.

Indexed as

RadiosurgeryBone NeoplasmsBrain NeoplasmsCarboplatinChemotherapy, AdjuvantFemaleHumansMiddle AgedNeoplasm StagingPaclitaxelThymomaThymus NeoplasmsTreatment OutcomeCarboplatinPaclitaxel

Identifiers

PMID31719514
PMCPMC6870759
OpenAlexW2987208835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.