ArticleNeural regeneration research2020
Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction.
Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Potential Biomarkers of Post-stroke Cognitive Impairment in Chinese Population: a Systematic Review and Meta-Analysis.Molecular neurobiology · 2025Pooled it
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Molecular biomarkers of cognitive impairment and neuropsychiatric symptoms after stroke in late-life-enriched cohorts: a scoping review.Journal of translational medicine · 2026Article
- Long-term cystatin C trajectories and cognitive decline in diabetes and non-diabetes: evidence from a national Chinese cohort.Frontiers in medicine · 2026Article
- Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study.Molecular neurobiology · 2025Article
- Association between initial serum cystatin C level and prognosis of aneurysmal subarachnoid hemorrhage.BMC neurology · 2025Article
- Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke.Frontiers in endocrinology · 2025Review
- Lower serum cystatin C level predicts poor functional outcome in patients with hypertensive intracerebral hemorrhage independent of renal function.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Impact of Serum Cystatin C Level on Long-Term Cognitive Impairment After Acute Ischemic Stroke and Transient Ischemic Attack.Neuropsychiatric disease and treatment · 2023Article
- The expression profiling of serum miR-92a, miR-134 and miR-375 in acute ischemic stroke.Future science OA · 2022Article
- Association between serum cystatin C level and post-stroke cognitive impairment in patients with acute mild ischemic stroke.Brain and behavior · 2022Article
- The Effects of Enriched Rehabilitation on Cognitive Function and Serum Glutamate Levels Post-stroke.Frontiers in neurology · 2022Article
- Association of sleep characteristics with renal function in menopausal women without recognized chronic kidney disease.Frontiers in psychiatry · 2022Article
- Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits.Neural regeneration research · 2021Article
- Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke.Neural regeneration research · 2021Article
- Association Cystatin C and Risk of Stroke in Elderly Patients With Obstructive Sleep Apnea: A Prospective Cohort Study.Frontiers in neuroscience · 2021Article
- Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2021Observational
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Stroke is the leading cause of death and long-term disability worldwide, and cognitive impairment and dementia are major complications of ischemic stroke. Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies. However, the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results. This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months. Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke. According to the MMSE score, 308 patients (52.9%) had post-stroke cognitive dysfunction. After adjusting for potential confounding factors, the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30-0.98), compared with the lowest quartile. The correlation between serum CysC and cognitive dysfunction was modified by renal function status. We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (P
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.