Evidence map›Paper›PMID 31719255›Full record

ArticleNeural regeneration research2020

Rosmarinic acid ameliorates hypoxia/ischemia induced cognitive deficits and promotes remyelination.

Man Li, Miao-Miao Cui, Nwobodo Alexander Kenechukwu, Yi-Wei Gu, Yu-Lin Chen, Si-Jing Zhong, Yu-Ting Gao, Xue-Yan Cao, Li Wang, Fu-Min Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Rosemary (Iranian journal of basic medical sciences · 2026
    Review
  3. Effects ofToxics · 2023
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Man LiDepartment of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Miao-Miao CuiDepartment of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Nwobodo Alexander KenechukwuDepartment of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Yi-Wei GuDepartment of Urology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Yu-Lin ChenDepartment of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Si-Jing ZhongXuzhou Medical University Clinical Medical College, Xuzhou, Jiangsu Province, China.
Yu-Ting GaoDepartment of Clinical Laboratory, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Xue-Yan CaoDepartment of Urology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Li WangDepartment of Urology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Fu-Min LiuDepartment of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Xiang-Ru WenResearch Center for Neurobiology and Department of Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Xuzhou Medical College · CNFirst Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosmarinic acid, a common ester extracted from Rosemary, Perilla frutescens, and Salvia miltiorrhiza Bunge, has been shown to have protective effects against various diseases. This is an investigation into whether rosmarinic acid can also affect the changes of white matter fibers and cognitive deficits caused by hypoxic injury. The right common carotid artery of 3-day-old rats was ligated for 2 hours. The rats were then prewarmed in a plastic container with holes in the lid, which was placed in 37°C water bath for 30 minutes. Afterwards, the rats were exposed to an atmosphere with 8% O

Indexed as

cognitive dysfunctioncorpus callosumdifferentiation/DNA binding factor 2hypoxia/ischemiamyelin basic proteinmyelin sheathremyelinationrosmarinic acid

Identifiers

PMID31719255
PMCPMC6990785
OpenAlexW2984943542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.