ReviewJournal of biosciences2019
Decoding the microbiome for the development of translational applications: Overview, challenges and pitfalls.
Review in Journal of biosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
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Abstract
Recent studies have highlighted the potential of 'translational' microbiome research in addressing real-world challenges pertaining to human health, nutrition and disease. Additionally, outcomes of microbiome research have also positively impacted various aspects pertaining to agricultural productivity, fuel or energy requirements, and stability/preservation of various ecological habitats. Microbiome data is multi-dimensional with various types of data comprising nucleic and protein sequences, metabolites as well as various metadata related to host and or environment. This poses a major challenge for computational analysis and interpretation of data to reach meaningful, reproducible (and replicable) biological conclusions. In this review, we first describe various aspects of microbiomes that make them an attractive tool/target for developing various translational applications. The challenge of deciphering signatures from an information-rich resource like the microbiome is also discussed. Subsequently, we present three case-studies that exemplify the potential of microbiome- based solutions in solving real-world problems. The final part of the review attempts to familiarize readers with the importance of a robust study design and the diligence required during every stage of analysis for achieving solutions with potential translational value.
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Identifiers
31719227What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.