ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Graded Coexpression of Ion Channel, Neurofilament, and Synaptic Genes in Fast-Spiking Vestibular Nucleus Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Higher-order interactions in neuronal function: From genes to ionic currents in biophysical models.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Transmitter and ion channel profiles of saccadic omnipause neurons and cholinergic non-omnipause neurons in human nucleus raphe interpositus.Frontiers in neuroanatomy · 2025Article
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
- Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons.Cell reports · 2024Article
- Ion channel profiles of extraocular motoneurons and internuclear neurons in human abducens and trochlear nuclei.Frontiers in neuroanatomy · 2024Article
- Cell type specializations of the vocal-motor cortex in songbirds.Cell reports · 2023Article
- Molecular profiling of COComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes.eLife · 2023Article
- Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization.Current biology : CB · 2023Article
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
- Resurgent NaNature communications · 2021Article
- Histochemical Characterization of the Vestibular Y-Group in Monkey.Cerebellum (London, England) · 2021Article
- Transmitter and ion channel profiles of neurons in the primate abducens and trochlear nuclei.Brain structure & function · 2021Article
- Neural variability determines coding strategies for natural self-motion in macaque monkeys.eLife · 2020Article
- Persistent and resurgent NaJournal of neurophysiology · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Computations that require speed and temporal precision are implemented throughout the nervous system by neurons capable of firing at very high rates, rapidly encoding and transmitting a rich amount of information, but with substantial metabolic and physical costs. For economical fast spiking and high throughput information processing, neurons need to optimize multiple biophysical properties in parallel, but the mechanisms of this coordination remain unknown. We hypothesized that coordinated gene expression may underlie the coordinated tuning of the biophysical properties required for rapid firing and signal transmission. Taking advantage of the diversity of fast-spiking cell types in the medial vestibular nucleus of mice of both sexes, we examined the relationship between gene expression, ionic currents, and neuronal firing capacity. Across excitatory and inhibitory cell types, genes encoding voltage-gated ion channels responsible for depolarizing and repolarizing the action potential were tightly coexpressed, and their absolute expression levels increased with maximal firing rate. Remarkably, this coordinated gene expression extended to neurofilaments and specific presynaptic molecules, providing a mechanism for coregulating axon caliber and transmitter release to match firing capacity. These findings suggest the presence of a module of genes, which is coexpressed in a graded manner and jointly tunes multiple biophysical properties for economical differentiation of firing capacity. The graded tuning of fast-spiking capacity by the absolute expression levels of specific ion channels provides a counterexample to the widely held assumption that cell-type-specific firing patterns can be achieved via a vast combination of different ion channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.