ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Temporal Coding of Single Auditory Nerve Fibers Is Not Degraded in Aging Gerbils.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- The auditory nerve glial transition zone is a focal site of age-related immune-myelin interactions.Frontiers in immunology · 2026Article
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Degraded neural coding of temporal fine structure with age predicts effortful listening in multi-talker environments.bioRxiv : the preprint server for biology · 2025Article
- Auditory brainstem responses in two closely related Peromyscus species (Peromyscus leucopus and Peromyscus maniculatus).The Journal of the Acoustical Society of America · 2025Article
- Age-Related Decline in Neural Phase-Locking to Envelope and Temporal Fine Structure Revealed by Frequency Following Responses: A Potential Signature of Cochlear Synaptopathy Impairing Speech Intelligibility.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Speech sound discrimination in background noise across the lifespan: a comparative study in Mongolian gerbils and humans.Frontiers in aging neuroscience · 2025Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Single-unit data for sensory neuroscience: Responses from the auditory nerve of young-adult and aging gerbils.Scientific data · 2024Article
- Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distribution of Vasopressin 1a and Oxytocin Receptor Binding in the Basal Forebrain and Midbrain of Male and Female Mongolian Gerbils.Neuroscience · 2023Article
- Altered neural encoding of vowels in noise does not affect behavioral vowel discrimination in gerbils with age-related hearing loss.Frontiers in neuroscience · 2023Article
- Physiological Evidence for Delayed Age-related Hearing Loss in Two Long-lived Rodent Species (Peromyscus leucopus and P. californicus).Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Sound source localization patterns and bilateral cochlear implants: Age at onset of deafness effects.PloS one · 2022Article
- Olivocochlear projections contribute to superior intensity coding in cochlear nucleus small cells.The Journal of physiology · 2022Article
- Establishment of Noninvasive Methods for the Detection ofBioMed research international · 2022Article
- Aging Effects on Cortical Responses to Tones and Speech in Adult Cochlear-Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Modeling the effects of age and hearing loss on concurrent vowel scores.The Journal of the Acoustical Society of America · 2021Article
- Robustness of neuronal tuning to binaural sound localization cues against age-related loss of inhibitory synaptic inputs.PLoS computational biology · 2021Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
People suffering from age-related hearing loss typically present with deficits in temporal processing tasks. Temporal processing deficits have also been shown in single-unit studies at the level of the auditory brainstem, midbrain, and cortex of aged animals. In this study, we explored whether temporal coding is already affected at the level of the input to the central auditory system. Single-unit auditory nerve fiber recordings were obtained from 41 Mongolian gerbils of either sex, divided between young, middle-aged, and old gerbils. Temporal coding quality was evaluated as vector strength in response to tones at best frequency, and by constructing shuffled and cross-stimulus autocorrelograms, and reverse correlations, from responses to 1 s noise bursts at 10-30 dB sensation level (dB above threshold). At comparable sensation levels, all measures showed that temporal coding was not altered in auditory nerve fibers of aging gerbils. Furthermore, both temporal fine structure and envelope coding remained unaffected. However, spontaneous rates were decreased in aging gerbils. Importantly, despite elevated pure tone thresholds, the frequency tuning of auditory nerve fibers was not affected. These results suggest that age-related temporal coding deficits arise more centrally, possibly due to a loss of auditory nerve fibers (or their peripheral synapses) but not due to qualitative changes in the responses of remaining auditory nerve fibers. The reduced spontaneous rate and elevated thresholds, but normal frequency tuning, of aged auditory nerve fibers can be explained by the well known reduction of endocochlear potential due to strial dysfunction in aged gerbils.
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