Evidence map›Paper›PMID 31719136›Full record

ArticleNeurology2019

Physical activity and prodromal features of Parkinson disease.

Katherine C Hughes, Xiang Gao, Samantha Molsberry, Linda Valeri, Michael A Schwarzschild, Alberto Ascherio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Pooled it
  2. Review
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  4. Observational
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  12. Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024
    Review
  13. Physical activity and sleep pattern in relation to incident Parkinson's disease: a cohort study.The international journal of behavioral nutrition and physical activity · 2024
    Article
  14. Review
  15. Article
  16. Parkinson's Disease: A Tale of Many Players.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Katherine C HughesFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. kch460@mail.harvard.edu.
Xiang GaoFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Samantha MolsberryFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Linda ValeriFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Michael A SchwarzschildFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Alberto AscherioFrom the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Massachusetts General Hospital · USColumbia University · USHarvard University · USMaineGeneral Medical Center · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

objectiveTo investigate the relationship between physical activity and prodromal features of Parkinson disease that often precede the clinical diagnosis.

methodsIncluded are participants in 2 well-established cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Physical activity was assessed using validated questionnaires at baseline (1986) and every 2 years until 2008. Prodromal features (e.g., constipation, hyposmia, and probable REM sleep behavior disorder [pRBD]) were assessed in 2012-2014.

resultsThe multivariable-adjusted odds ratio (OR) for having ≥3 prodromal features vs none comparing the highest to the lowest quintile were 0.65 (95% confidence interval [CI] 0.53-0.79;

conclusionsThe reduced prevalence of prodromal features associated with Parkinson disease in older individuals who were more physically active in midlife and beyond is consistent with the hypothesis that high levels of physical activity may reduce risk of Parkinson disease.

Indexed as

Prodromal SymptomsAdultAgedCohort StudiesExerciseFemaleHumansMaleMiddle AgedParkinson Disease

Identifiers

PMID31719136
PMCPMC6937486
OpenAlexW2983618849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.