Evidence map›Paper›PMID 31719125›Full record

ArticleRNA (New York, N.Y.)2020

Deep sequencing of tRNA's 3'-termini sheds light on CCA-tail integrity and maturation.

Andreas Czech

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. The landscape of Arabidopsis tRNA aminoacylation.The Plant journal : for cell and molecular biology · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Triplet-Encoded Prebiotic RNA Aminoacylation.Journal of the American Chemical Society · 2023
    Article
  6. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  7. Article
  8. Accurate characterization ofRNA biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Andreas CzechInstitute of Biochemistry and Molecular Biology, Chemistry Department, University of Hamburg, 20146 Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 3'-termini of tRNA are the point of amino acid linkage and thus crucial for their function in delivering amino acids to the ribosome and other enzymes. Therefore, to provide tRNA functionality, cells have to ensure the integrity of the 3'-terminal CCA-tail, which is generated during maturation by the 3'-trailer processing machinery and maintained by the CCA-adding enzyme. We developed a new tRNA sequencing method that is specifically tailored to assess the 3'-termini of

Indexed as

High-Throughput Nucleotide SequencingEscherichia coliEscherichia coli ProteinsExoribonucleasesNucleotidesRNA 3' End ProcessingRNA, BacterialRNA NucleotidyltransferasesRNA PrecursorsRNA StabilityRNA, TransferSequence Analysis, RNAEscherichia coli ProteinsExoribonucleasesexoribonuclease TNucleotidesRNA, BacterialRNA NucleotidyltransferasesRNA PrecursorsRNA, TransfertRNA nucleotidyltransferaseCCA-adding enzymeCCA-taildeep sequencingRNase TtRNA integritytRNA maturation

Identifiers

PMID31719125
PMCPMC6961547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.