Evidence map›Paper›PMID 31719065›Full record

SynthesisCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer.

M Constanza Camargo, Kyoung-Mee Kim, Keitaro Matsuo, Javier Torres, Linda M Liao, Douglas Morgan, Angelika Michel, Tim Waterboer, Minkyo Song, Margaret L Gulley and 8 more

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Comparative Microbiomics Analysis of Antimicrobial Antibody Response between Patients with Lung Cancer and Control Subjects with Benign Pulmonary Nodules.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 7 countries.

M Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. camargomc@mail.nih.gov.
Kyoung-Mee KimDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID 0000-0002-1162-9205
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan.ORCID 0000-0003-1761-6314
Javier TorresUnidad de Investigación en Enfermedades Infecciosas, UMAE Pediatría, CMN SXXI, Instituto Mexicano del Seguro Social, México City, México.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Douglas MorganDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Angelika MichelInfections and Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany.
Minkyo SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.ORCID 0000-0002-9412-2871
Margaret L GulleyDepartment of Pathology and Laboratory Medicine and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.
Ricardo L DominguezDepartment of Medicine, Western Regional Hospital, Santa Rosa de Copan, Honduras.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.ORCID 0000-0003-1788-559X
Sung KimDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID 0000-0002-1162-9205
Gustavo Cortes-MartinezServicio de Cirugía, Hospital de Oncología, CMN SXXI, Instituto Mexicano del Seguro Social, México City, México.
Jolanta LissowskaDivision of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.ORCID 0000-0003-2695-5799
Jovanny ZabaletaStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Michael PawlitaInfections and Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany.ORCID 0000-0002-4720-8306
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
National Cancer Institute · USGerman Cancer Research Center · DEAichi Cancer Center · JPMexican Social Security Institute · MXSamsung Medical Center · KRLouisiana State University Health Sciences Center New Orleans · USThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of North Carolina at Chapel Hill · USVanderbilt University · USWestern Regional Hospital · NP

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
Mentoring Translational Researchers in LouisianaP20GM103501 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2012 to 2014
$6.3M
Targeted chemoprevention of gastric carcinogenesis in high risk populationsR01CA190612 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, DOUGLAS, WILSON, KEITH T. · 2014 to 2018
$3.0M
Gastric Cancer Epidemiology Initiative in Central AmericaK07CA125588 · NCI · VANDERBILT UNIVERSITY · PI MORGAN, DOUGLAS · 2007 to 2011
$680k
NCI NIH HHS K07 CA125588NCI NIH HHS P01 CA028842NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA190612NIGMS NIH HHS P20 GM103501NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundEpstein-Barr virus (EBV)-positive gastric cancers have clinicopathologic differences from EBV-negative tumors and lack

methodsWe compared humoral responses of EBV-positive (

resultsConsistent with EBV's ubiquity, 99% of patients were seropositive for anti-EBNA and 98% for anti-VCA, without difference by tumor EBV status. Seropositivity varied between patients with EBV-positive and EBV-negative tumors for anti-EA-D (97% vs. 67%, respectively,

conclusionsThese serologic patterns suggest viral reactivation in EBV-positive cancers and identify variation of p53 seropositivity by subtype. IMPACT: Anti-EBV and anti-p53 antibodies are differentially associated with tumor EBV positivity. Serology may identify EBV-positive gastric cancer for targeted therapies.

Indexed as

Antibodies, ViralCapsidCarcinogenesisEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleHerpesvirus 4, HumanHumansMaleMiddle AgedSerologic TestsStomach NeoplasmsTumor Suppressor Protein p53Virus ActivationAntibodies, ViralEpstein-Barr Virus Nuclear AntigensTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID31719065
PMCPMC8272980
OpenAlexW2989439738

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.