Evidence map›Paper›PMID 31718786›Full record

ArticleEnvironmental research2020

Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation.

Daniel W Riggs, Nagma Zafar, Sathya Krishnasamy, Ray Yeager, Shesh N Rai, Aruni Bhatnagar, Timothy E O'Toole

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
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  9. Senolytics Reverse PMCardiovascular toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel W RiggsChristina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, 40292, USA; Department of Bioinformatics and Biostatics, University of Louisville, Louisville, KY, 40292, USA.
Nagma ZafarDepartment of Pediatrics, University of Louisville, Louisville, KY, 40292, USA.
Sathya KrishnasamyDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Louisville, Louisville, KY, 40292, USA.
Ray YeagerChristina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, 40292, USA.
Shesh N RaiChristina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, 40292, USA; Department of Bioinformatics and Biostatics, University of Louisville, Louisville, KY, 40292, USA; Biostatistics and Bioinformatics Facility, JG Brown Cancer Center, University of Louisville, Louisville, KY, 40292, USA.
Aruni BhatnagarChristina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, 40292, USA.
Timothy E O'TooleChristina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, 40292, USA. Electronic address: tim.otoole@louisville.edu.
University of Louisville · US

Funding

Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI SRIVASTAVA, SANJAY · 2017 to 2025
$18.1M
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2018 to 2022
$6.3M
Urban Greenness and Cardiovascular HealthR01ES029846 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Aruni Bhatnagar · 2018 to 2026
$6.2M
Endothelial Progenitor Cells and Particulate Air PollutionR01ES019217 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI, O'TOOLE, TIMOTHY E · 2011 to 2022
$6.0M
NIEHS NIH HHS P42 ES023716NIEHS NIH HHS R01 ES019217NIEHS NIH HHS R01 ES029846NIGMS NIH HHS P30 GM127607
6 · The paper itself

Abstract

Epidemiological evidence suggests that exposure to air pollution is a leading risk factor for cardiovascular disease (CVD). However, there is little direct evidence linking exposure to vascular dysfunction. We conducted a cross-sectional study of 100 participants, recruited from the University of Louisville Clinics. Endothelial function was assessed by calculating the reactive hyperemia index (RHI). Oxidative stress was indexed by measuring urinary levels of isoprostanes (n = 91). Inflammatory biomarkers were measured in the plasma (n = 80). Daily average PM

Indexed as

Air PollutantsAir PollutionInflammationOxidative StressParticulate MatterBiomarkersCross-Sectional StudiesEnvironmental ExposureFemaleHumansMaleMiddle AgedPlacenta Growth FactorVascular Endothelial Growth Factor AAir PollutantsBiomarkersParticulate MatterPlacenta Growth FactorVascular Endothelial Growth Factor AAir pollutionCytokinesEndothelial dysfunctionIsoprostanesPM(2.5)Reactive hyperemia index

Identifiers

PMID31718786
PMCPMC6899204
OpenAlexW2987529241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.