ArticleeLife2019
Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis.Acta neuropathologica communications · 2026Article
- GSK-3β coordinates axonal microtubule organization through Shot and Tau.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function.Aging and disease · 2024Article
- The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.Cell reports · 2024Article
- KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons.Molecular biology of the cell · 2024Article
- A methodology for specific disruption of microtubule polymerization into dendritic spines.Molecular biology of the cell · 2024Article
- The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins.bioRxiv : the preprint server for biology · 2024Article
- A Methodology for Specific Disruption of Microtubules in Dendritic Spines.bioRxiv : the preprint server for biology · 2024Article
- Neuronal ageing is promoted by the decay of the microtubule cytoskeleton.PLoS biology · 2024Article
- Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila.Cell regeneration (London, England) · 2023Review
- How neurons maintain their axons long-term: an integrated view of axon biology and pathology.Frontiers in neuroscience · 2023Review
- Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.Brain : a journal of neurology · 2022Article
- Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance.Developmental neurobiology · 2022Article
- Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila.EMBO reports · 2021Article
- Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons.PLoS genetics · 2021Article
- Cell-type-specific, multicolor labeling of endogenous proteins with split fluorescent protein tags inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor.Cells · 2021Review
- Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.JCI insight · 2021Article
- Dynamic sex chromosome expression in Drosophila male germ cells.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Yue Qu *Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.
Ines Hahn *Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-7703-8160
Meredith LeesManchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.
Jill ParkinManchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.
André VoelzmannManchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-7682-5637
Karel DoreyFaculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0003-0846-5286
Alex RathboneSchool of Life Sciences, Faculty of Medicine and Health Sciences, The University of Nottingham, Nottingham, United Kingdom.
Claire T FrielSchool of Life Sciences, Faculty of Medicine and Health Sciences, The University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0001-8395-5301
Victoria J AllanManchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0003-4583-0836
Pilar Okenve-RamosDepartment of Cellular and Molecular Physiology,Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-7513-6557
Natalia Sanchez-SorianoDepartment of Cellular and Molecular Physiology,Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-6667-2817
Andreas ProkopManchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-8482-3298
Manchester Academic Health Science Centre · GBUniversity of Liverpool · GBUniversity of Nottingham · GBUniversity of Manchester · GB
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MBBSRC BB/R018960/1Biotechnology and Biological Sciences Research Council BB/I002448/1Biotechnology and Biological Sciences Research Council BB/J005983/1Biotechnology and Biological Sciences Research Council BB/L000717/1Biotechnology and Biological Sciences Research Council BB/M007456/1Biotechnology and Biological Sciences Research Council BB/M007553/1Biotechnology and Biological Sciences Research Council BB/P020151/1Deutsche Forschungsgemeinschaft VO 2071/1-1Leverhulme Trust ECF-2017-247NIH HHS P40 OD018537Wellcome Trust
Abstract
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in
Indexed as
PolymerizationAmino Acid MotifsAnimalsAxonsCell MembraneCells, CulturedDrosophila melanogasterDrosophila ProteinsFibroblastsGreen Fluorescent ProteinsGrowth ConesGuanine Nucleotide Exchange FactorsMembrane ProteinsMiceMicrotubulesNIH 3T3 CellsDrosophila ProteinsEfa6 protein, DrosophilaGreen Fluorescent ProteinsGuanine Nucleotide Exchange FactorsMembrane ProteinsPeptidesPsd protein, mouseaxonscell biologycytoskeletondevelopmental biologyD. melanogasterDrosophilamicrotubulesmouseneurodegenerationxenopus
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.