ArticleMilitary Medical Research2019
Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study.
Article in Military Medical Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Association between periodontal disease and prostatic disease: a systematic review and meta-analysis of observational studies.The Canadian journal of urology · 2026Pooled it
- Is There Any Association Between Periodontitis and Prostatic Alterations? A Systematic Review.The Prostate · 2025Pooled it
- Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study.Journal of translational medicine · 2022Pooled it
- Effects of non-surgical periodontal therapy on prostate-specific antigen levels and recurrent urinary tract infections: a randomized controlled clinical study.Scientific reports · 2026Trial
- Association between Periodontal Status and Prognosis in Men with Prostatitis: A Cross-Sectional Clinical Study.European journal of dentistry · 2026Article
- Exploring the therapeutic potential of Astragalin in Parkinson's disease: a network pharmacology approach.Annals of medicine and surgery (2012) · 2026Article
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Oral microbiota and urinary system diseases: from mechanistic insights to clinical implications-a comprehensive review.Frontiers in dental medicine · 2026Review
- Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling.Journal of translational medicine · 2025Article
- Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study.Microbiology spectrum · 2025Article
- Chronic Periodontitis as a Risk Factor for Benign Prostatic Hyperplasia: A Cohort Study.Journal of clinical medicine · 2025Article
- Causal relationship between periodontitis and prostate diseases: a bidirectional Mendelian randomization study.Clinical oral investigations · 2025Article
- Beyond antibiotics: advances in photothermal strategies for oral infections.Frontiers in bioengineering and biotechnology · 2025Review
- Association between periodontal disease and prostate disease: a mini review.Frontiers in cellular and infection microbiology · 2025Review
- The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review.Frontiers in microbiology · 2025Review
- The role of gut microbiota in prostate inflammation and benign prostatic hyperplasia and its therapeutic implications.Heliyon · 2024Review
- Association between periodontal disease and schizophrenia: a bidirectional two-sample Mendelian randomization study.Scientific reports · 2024Article
- P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway.Military Medical Research · 2024Article
- Biomaterials science and surface engineering strategies for dental peri-implantitis management.Military Medical Research · 2024Review
- Causal associations of immune cells with benign prostatic hyperplasia: insights from a Mendelian randomization study.World journal of urology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence, this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia.
methodsA total of 4930 participants were selected from an available health examination that was carried out in 2017, only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups, the benign prostatic hyperplasia group was then divided into prostate volume ≤ 60 g and > 60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0), periodontal disease (CPI score between 1 and 4), and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software.
resultsA total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (OR = 1.68, 95% CI: 1.26-2.24), and individuals with periodontitis showed a higher risk (OR = 4.18, 95% CI: 2.75-6.35). In addition, among matched cases and controls, this association remained robust (periodontal disease: OR = 1.85, 95% CI: 1.30-2.64; periodontitis: OR = 4.83, 95% CI: 2.57-9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤ 60 g: OR = 1.64, 95% CI: 1.22-2.20; for volume > 60 g: OR = 2.17, 95% CI: 1.04-4.53), and there was a higher risk in the group with a prostate volume greater than 60 g.
conclusionPeriodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.
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