Evidence map›Paper›PMID 31718702›Full record

ArticleItalian journal of pediatrics2019

Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria.

I E Ocheke, S Mohamed, E S Okpe, F Bode-Thomas, M I McCullouch

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07708714 (Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07708714 phase1 / phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas: The NOHARM Maximum Tolerated Dose (MTD) Study

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2026 to 2032Enrolled250ConditionsSickle Cell Disease, Sickle Cell Anemia in ChildrenArmshydroxycarbamide
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

I E OchekeDepartment of Paediatrics, Jos University Teaching Hospital, Jos, PMB 2076, Nigeria. ieocheke@yahoo.com.
S MohamedDepartment of Paediatrics, Jos University Teaching Hospital, Jos, PMB 2076, Nigeria.
E S OkpeDepartment of Paediatrics, Jos University Teaching Hospital, Jos, PMB 2076, Nigeria.
F Bode-ThomasDepartment of Paediatrics, Jos University Teaching Hospital, Jos, PMB 2076, Nigeria.
M I McCullouchRed Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Jos University Teaching Hospital · NGUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEvidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate.

methodsThis was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period.

resultMicroalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953-1.116, p = 0.003 and OR = 1.7, CI 1.042-1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01).

conclusionsThe two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control.

Indexed as

Glomerular Filtration RateAdolescentAlbuminuriaAnemia, Sickle CellCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantMaleNigeriaPrevalenceRisk FactorsChildrenEstimated glomerular filtration rateMicroalbuminuriaRiskSickle cell anaemia

Identifiers

PMID31718702
PMCPMC6852760
OpenAlexW2989095841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.