Evidence map›Paper›PMID 31718676›Full record

Observational studyRespiratory research2019

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.

J Michael Wells, Dongqi Xing, Liliana Viera, Robert M Burkes, Yixin Wu, Surya P Bhatt, Mark T Dransfield, David J Couper, Wanda O'Neal, Eric A Hoffman and 10 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025
    Article
  3. Article
  4. Article
  5. Advances in metabolomics of chronic obstructive pulmonary disease.Chinese medical journal pulmonary and critical care medicine · 2023
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

J Michael WellsDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. jmwells@uabmc.edu.
Dongqi XingDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Liliana VieraDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Robert M BurkesDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yixin WuDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Surya P BhattDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Mark T DransfieldDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David J CouperGillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wanda O'NealDepartment of Medicine, University of North Carolina at Chapel HillMarsico Lung Institute/Cystic Fibrosis Research Center, Chapel Hill, NC, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Amit GaggarDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, University of California-Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan-Ann Arbor, Ann Arbor, MI, USA.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan-Ann Arbor, Ann Arbor, MI, USA.
Mei Lan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan-Ann Arbor, Ann Arbor, MI, USA.
Christine M FreemanDivision of Pulmonary and Critical Care Medicine, University of Michigan-Ann Arbor, Ann Arbor, MI, USA.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Thomas SchlangeBayer AG, AG, Pharmaceutical Division, Wuppertal, Germany.
J Edwin BlalockDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
SPIROMICS Investigators,
University of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Michigan · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
A Novel Exosomal Inflammatory PathwayR35HL135710 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2017 to 2023
$6.8M
A Novel Proteolytic System of Pulmonary InflammationR01HL102371 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2021
$3.3M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
Genetics of Smoke-Altered LTA4H in COPDR01HL126596 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN, CASTALDI, PETER · 2015 to 2018
$1.6M
PGP, A Possible Biomarker for COPD Exacerbations and or ProgressionR01HL114439 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$1.5M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
The Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
BLRD VA I01 BX001756CSRD VA I01 CX000911CSRD VA I01 CX001553National Heart, Lung, and Blood Institute (US) HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, HHSN268200900020C, U01 HL137880National Heart, Lung, and Blood Institute (US) R01HL114439, R01HL126596,and R35HL135710NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K08 HL123940NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL140108NHLBI NIH HHS R01 HL102371NHLBI NIH HHS R01 HL114439NHLBI NIH HHS R01 HL126596NHLBI NIH HHS R35 HL135710NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526U.S. Department of Veterans Affairs I01BX001756
6 · The paper itself

Abstract

backgroundPulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD.

methodsSputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment. AcPGP was isolated using solid phase extraction and measured by mass spectrometry. Demographics, spirometry, quality of life questionnaires, and quantitative computed tomography (CT) imaging with parametric response mapping (PRM) were obtained at baseline. Severe COPD exacerbations were recorded at 1-year of prospective follow-up. We used linear and logistic regression models to measure associations between AcPGP and features of COPD, and Kaplan-Meier analyses to measure time-to-first severe exacerbation.

resultsThe 182 COPD participants in the analysis were 66 ± 8 years old, 62% male, 84% White race, and 39% were current smokers. AcPGP concentrations were 0.61 ± 1.89 ng/mL (mean ± SD) in sputum and 0.60 ± 1.13 ng/mL in plasma. In adjusted linear regression models, sputum AcPGP was associated with FEV

conclusionsIn COPD, sputum but not plasma AcPGP concentrations are associated with the severity of airflow limitation, small airways disease, emphysema, and risk for severe AECOPD at 1-year of follow-up.

trial registrationClinicalTrials.gov: NCT01969344 (SPIROMICS).

Indexed as

AgedBiomarkersCohort StudiesFemaleGlycineHumansMaleMiddle AgedProlineProspective StudiesPulmonary Disease, Chronic ObstructiveSpirometrySputumBiomarkersGlycineProlineAcetyl proline-glycine-proline (AcPGP)BiomarkerCOPDInflammationMatrikineSputum

Identifiers

PMID31718676
PMCPMC6852714
OpenAlexW2989192946

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.