Evidence map›Paper›PMID 31718670›Full record

ArticleRadiation oncology (London, England)2019

Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions.

Thomas Held, Paul Windisch, Sati Akbaba, Kristin Lang, Benjamin Farnia, Jakob Liermann, Denise Bernhardt, Peter Plinkert, Christian Freudlsperger, Stefan Rieken and 3 more

Abstract read
In one paragraph

Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Particle therapy in the future of precision therapy.The British journal of radiology · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thomas HeldDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Paul WindischDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Sati AkbabaDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Kristin LangDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Benjamin FarniaDepartment of Radiation Oncology, University of Miami, Miami, Florida, USA.
Jakob LiermannDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Denise BernhardtDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Peter PlinkertDepartment of Otorhinolaryngology, University of Heidelberg, Heidelberg, Germany.
Christian FreudlspergerDepartment of Oral and Maxillofacial Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Stefan RiekenDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Klaus HerfarthDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Sebastian AdebergDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany. sebastian.adeberg@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-8463-514X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work.

methodsThirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity.

resultsMucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD

conclusionsCIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications.

Indexed as

AgedCarcinoma, MucoepidermoidDisease-Free SurvivalFemaleFollow-Up StudiesHead and Neck NeoplasmsHeavy Ion RadiotherapyHumansMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPalliative CarePrognosisRare DiseasesRe-IrradiationCarbon ionsHead and neck cancerMucoepidermoid carcinomaParticle therapySalvage re-irradiation

Identifiers

PMID31718670
PMCPMC6852923

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.