ArticleBMC complementary and alternative medicine2019
Heracleum moellendorffii roots inhibit the production of pro-inflammatory mediators through the inhibition of NF-κB and MAPK signaling, and activation of ROS/Nrf2/HO-1 signaling in LPS-stimulated RAW264.7 cells.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Antioxidant, Anti-Inflammatory, and Antiproliferative Activity of a Callus Culture ofPlants (Basel, Switzerland) · 2025Article
- Anti-Inflammatory Compounds From Roots of Heracleum sphondylium subsp. cyclocarpum.Chemical biology & drug design · 2025Article
- AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice.Molecular medicine (Cambridge, Mass.) · 2025Article
- The complete chloroplast genome ofMitochondrial DNA. Part B, Resources · 2025Article
- Multiomic analysis reveals that the flavonoid biosynthesis pathway is associated with cold tolerance inFrontiers in plant science · 2025Article
- Protective Effects and Mechanism ofInternational journal of molecular sciences · 2024Article
- Antidepressant Effect ofNutrients · 2024Article
- Phytochemical investigation and assessment of the anti-inflammatory activity of fourFrontiers in pharmacology · 2024Article
- Heme Oxygenase 1-Mediated Anti-Inflammatory Effect of Extract from the Aerial Part ofFoods (Basel, Switzerland) · 2023Article
- Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention.Foods (Basel, Switzerland) · 2023Review
- Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways.Frontiers in pharmacology · 2023Article
- Identification, In Silico Characterization, and Differential Expression Profiles of Carotenoid, Xanthophyll, Apocarotenoid Biosynthetic Pathways Genes, and Analysis of Carotenoid and Xanthophyll Accumulation inInternational journal of molecular sciences · 2022Article
- Anti-obesity activity ofFood science & nutrition · 2021Article
- Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics.Molecules (Basel, Switzerland) · 2021Article
- Article
- Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Bergenin Monohydrate Attenuates Inflammatory Response via MAPK and NF-κB Pathways AgainstFrontiers in pharmacology · 2021Article
- Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeracleum moellendorffii roots (HM-R) have been long treated for inflammatory diseases such as arthritis, backache and fever. However, an anti-inflammatory effect and the specific mechanism of HM-R were not yet clear. In this study, we for the first time explored the anti-inflammatory of HM-R.
methodsThe cytotoxicity of HM-R against RAW264.7 cells was evaluated using MTT assay. The inhibition of NO and PGE
resultsHM-R dose-dependently blocked LPS-induced NO and PGE
conclusionsThese results indicate that HM-R may exert anti-inflammatory activity by inhibiting NF-κB and MAPK signaling, and activating ROS/Nrf2/HO-1 signaling. These findings suggest that HM-R has a potential as a natural material for the development of anti-inflammatory drugs.
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Registered trials
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