ArticleBMC genetics2019
SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies.
Article in BMC genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
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- Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity.American journal of human genetics · 2022Article
- Battle for supremacy: nucleic acid interactions between viruses and cells.The Journal of clinical investigation · 2021Review
- Cox-sMBPLS: An Algorithm for Disease Survival Prediction and Multi-Omics Module Discovery IncorporatingFrontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOver the relatively short history of Genome Wide Association Studies (GWASs), hundreds of GWASs have been published and thousands of disease risk-associated SNPs have been identified. Summary statistics from the conducted GWASs are often available and can be used to identify SNP features associated with the level of GWAS statistical significance. Those features could be used to select SNPs from gray zones (SNPs that are nominally significant but do not reach the genome-wide level of significance) for targeted analyses.
methodsWe used summary statistics from recently published breast and lung cancer and scleroderma GWASs to explore the association between the level of the GWAS statistical significance and the expression quantitative trait loci (eQTL) status of the SNP. Data from the Genotype-Tissue Expression Project (GTEx) were used to identify eQTL SNPs.
resultsWe found that SNPs reported as eQTLs were more significant in GWAS (higher -log
conclusionsThe results of this study indicate that the SNP's eQTL status, as well as eQTL density in the adjacent region are positively associated with the level of statistical significance of the SNP in GWAS.
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Registered trials
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