Evidence map›Paper›PMID 31718265›Full record

ReviewChronic respiratory disease

Sarcoidosis and calcium homeostasis disturbances-Do we know where we stand?

Łukasz Gwadera, Adam Jerzy Białas, Mikołaj Aleksander Iwański, Paweł Górski, Wojciech Jerzy Piotrowski

Open access · goldAbstract readReview
In one paragraph

Review in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Contemporary management of sarcoidosis.Frontiers in medicine · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. I just hurt myself out in the garden… right?Breathe (Sheffield, England) · 2025
    Article
  12. Sarcoidosis presenting as thyromegaly.Medical journal, Armed Forces India · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Not all is what it seems like: Hypercalcemia in the older patient.Geriatrics & gerontology international · 2023
    Article
  18. A single-center rheumatology experience of sarcoidosis: observations from 70 patients.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Łukasz GwaderaDepartment of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland.
Adam Jerzy BiałasDepartment of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland.ORCID 0000-0002-3501-167X
Mikołaj Aleksander IwańskiDepartment of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland.
Paweł GórskiDepartment of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland.
Wojciech Jerzy PiotrowskiDepartment of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland.
Medical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.

Indexed as

HomeostasisBone DensityCalcitriolCalciumHumansHypercalcemiaPrognosisSarcoidosis, PulmonaryCalcitriolCalcium1,25(OH)2D325(OH)D3calcitriolcalciumhypercalcemiahypercalciuriaSarcoidosisvitamin D

Identifiers

PMID31718265
PMCPMC6854763
OpenAlexW2987662845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.