Evidence map›Paper›PMID 31718086›Full record

ArticleJournal of clinical medicine2019

Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study.

Vatsalya Vatsalya, Hamza Z Hassan, Maiying Kong, Bethany L Stangl, Melanie L Schwandt, Veronica Y Schmidt-Teron, Joris C Verster, Vijay A Ramchandani, Craig J McClain

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dysregulation in PlasmaAdvances in virology · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vatsalya VatsalyaDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0001-6764-6891
Hamza Z HassanDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.
Maiying KongDepartment of Bioinformatics and Biostatistics, SPHIS, University of Louisville, Louisville, KY 40202, USA.
Bethany L StanglNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Melanie L SchwandtNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Veronica Y Schmidt-TeronNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Joris C VersterDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-6455-2096
Vijay A RamchandaniNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.
Craig J McClainDepartment of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0002-7219-8939

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Novel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0M
Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7M
Mechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6M
Novel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5M
NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023681NIAAA NIH HHS U01AA021893-01NIAAA NIH HHS U01AA021901NIAAA NIH HHS U01AA022489-01A1NIAAA NIH HHS Z1A AA000466NIAAA NIH HHS Z99-AA999999NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Alcohol hangover is a combination of mental, sympathetic, and physical symptoms experienced the day after a single period of heavy drinking, starting when blood alcohol concentration approaches zero. How individual measures/domains of hangover symptomology might differ with moderate to heavy alcohol consumption and how these symptoms correlate with the drinking markers is unclear. We investigated the amount/patterns of drinking and hangover symptomology by the categories of alcohol drinking. We studied males and females in three groups: 12 heavy drinkers (HD; >15 drinks/week, 34-63 years old (y.o.)); 17 moderate drinkers (MD; 5-14 drinks/week, 21-30 y.o.); and 12 healthy controls (social/light drinkers, SD; <5 drinks/week, 25-54 y.o.). Demographics, drinking measures (Timeline followback past 90 days (TLFB90), Alcohol Use Disorders Identification Test (AUDIT)), and alcohol hangover scale (AHS) were analyzed. Average drinks/day was 5.1-times greater in HD compared to MD. Average AHS score showed moderate incapacity, and individual measures and domains of the AHS were significantly elevated in HD compared to MD. Symptoms of three domains of the AHS (mental, gastrointestinal, and sympathetic) showed domain-specific significant increase in HD. A domain-specific relation was present between AUDIT and specific measures of AHS scores in HD, specifically with the dependence symptoms. Exacerbation in hangover symptomology could be a marker of more severe alcohol use disorder.

Indexed as

alcohol hangover scale (AHS)alcohol use disorders identification test (AUDIT)dependence symptoms of AUDIT (DS-AUDIT)hangoverheavy drinking

Identifiers

PMID31718086
PMCPMC6912317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.