Evidence map›Paper›PMID 31718010›Full record

ReviewNutrients2019

Management of Cow's Milk Allergy from an Immunological Perspective: What Are the Options?

Edward F Knol, Nicolette W de Jong, Laurien H Ulfman, Machteld M Tiemessen

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in pediatrics · 2021
    Pooled it
  3. Pooled it
  4. Article
  5. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Edward F KnolCenter Translational Immunology, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.
Nicolette W de JongDept. Internal Medicine, section Allergology and Clinical Immunology, Erasmus MC, 3000 CA Rotterdam, The Netherlands.
Laurien H UlfmanFrieslandCampina, 3818 LE Amersfoort, The Netherlands.
Machteld M TiemessenDanone Nutricia Research, 3584 CT Utrecht, The Netherlands.
Erasmus MC · NLFrieslandCampina (Netherlands) · NLUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes is effective in the reduction of allergic symptoms but it cannot be envisioned as a treatment. For the treatment and prevention of IgE-mediated cow's milk allergy, it is thought that the induction of a sustained state of immunological tolerance is needed. In this review, we will discuss various approaches aimed at achieving immunological tolerance and their success. Furthermore, we will speculate on the involved immunological mechanism.

Indexed as

Milk HypersensitivityAdultAnimalsCattleChildHumansImmunoglobulin EInfantInfant FormulaImmunoglobulin Eallergycow’s milkformulaimmune cellsImmunoglubuline Etherapy

Identifiers

PMID31718010
PMCPMC6893795
OpenAlexW2985776119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.