ArticleJournal of clinical medicine2019
A Cross-Sectional Study of Hyponatremia Associated with Acute Central Nervous System Infections.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights.Endocrinology, diabetes & metabolism · 2026Review
- Hyponatremia Due to VZV-Induced SIADH in an Older Patient: Case Report and Literature Review.Infectious disease reports · 2025Article
- Clinical Significance of Hyponatremia in Tuberculous Meningitis: A Prospective Cohort in Indonesia.Open forum infectious diseases · 2024Article
- Association between hyponatremia and disease severity in pediatric urinary tract infections.BMC pediatrics · 2024Article
- Risk factors for hyponatremia in acute exacerbation chronic obstructive pulmonary disease (AECOPD): a multicenter cross-sectional study.BMC pulmonary medicine · 2023Article
- Case report: Fatal Borna virus encephalitis manifesting with basal brain and brainstem symptoms.Frontiers in neurology · 2023Article
- Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Higher plasma NT-proBNP levels correlate with syndrome of inappropriate antidiuretic hormone and poor prognosis in neurological patients.Annals of translational medicine · 2021Article
- Hyponatremia in Infectious Diseases-A Literature Review.International journal of environmental research and public health · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia can occur with central nervous system (CNS) infections, but the frequency and severity may depend on the organism and nature of CNS involvement. In this cross-sectional study at a large Australian hospital network from 2015 to 2018, we aimed to determine the prevalence and severity of hyponatremia associated with CNS infection clinical syndromes, and the association with specific organisms. We examined the results of cerebrospinal fluid analysis from lumbar punctures performed in 184 adult patients with a serum sodium below 135 mmol/L who had abnormal cerebrospinal fluid analysis and a clinical syndrome consistent with an acute CNS infection (meningitis or encephalitis). Hyponatremia affected 39% of patients and was more severe and frequent in patients with encephalitis compared to meningitis (odds ratio = 3.03, 95% CI: 1.43-6.39, after adjusting for age). Hyponatremia was present on admission in 85% of cases. Herpes simplex virus infection was associated with the highest odds of hyponatremia (odds ratio = 3.25, 95% CI: 1.13-7.87) while enterovirus infection was associated with the lowest (odds ratio = 0.36, 95% CI: 0.14-0.92), compared to cases without an isolated organism. We concluded that the risk of hyponatremia may vary by the organism isolated but the clinical syndrome was a useful surrogate for predicting the probability of developing hyponatremia.
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