Evidence map›Paper›PMID 31717805›Full record

ArticleNutrients2019

Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice.

Lucia A Seale, Vedbar S Khadka, Mark Menor, Guoxiang Xie, Ligia M Watanabe, Alexandru Sasuclark, Kyrillos Guirguis, Herena Y Ha, Ann C Hashimoto, Karolina Peplowska and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Effects of selenium supplementation on diet-induced obesity in mice with a disruption of the selenocysteine lyase gene.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lucia A SealeDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.ORCID 0000-0002-0686-7516
Vedbar S KhadkaDepartment of Quantitative Health Sciences, Bioinformatics Core Facility, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Mark MenorDepartment of Quantitative Health Sciences, Bioinformatics Core Facility, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Guoxiang XieCancer Biology Program and Metabolomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
Ligia M WatanabeDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.ORCID 0000-0001-7498-6165
Alexandru SasuclarkDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.
Kyrillos GuirguisDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.
Herena Y HaDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.
Ann C HashimotoDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.
Karolina PeplowskaPopulation Sciences in the Pacific Program and Genomics and Bioinformatics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
Maarit TiirikainenPopulation Sciences in the Pacific Program and Genomics and Bioinformatics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
Wei JiaCancer Biology Program and Metabolomics Shared Resource, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0002-3739-8994
Marla J BerryDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 93813, USA.
Youping DengDepartment of Quantitative Health Sciences, Bioinformatics Core Facility, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
University of Hawaiʻi at Mānoa · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MOKUAU, NOREEN, SHIRAMIZU, BRUCE T · 2012 to 2018
$21.1M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, RICHARD · 2015 to 2022
$8.1M
MECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTESR01DK047320 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 1994 to 2020
$5.8M
NCI NIH HHS P30 CA071789NIDDK NIH HHS R01 DK047320NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P30 GM114737NIH HHS 5P30GM114737NIH HHS G12MD007601 - CoreBucksNIH HHS P20GM103466NIH HHS P30CA071789-128NIH HHS R01DK47320NIH HHS U54MD007584NIH HHS U54MD007601 - Ola HAWAIINIH HHS U54MD007601 - subproject 5544NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Selenium is a nonmetal trace element that is critical for several redox reactions and utilized to produce the amino acid selenocysteine (Sec), which can be incorporated into selenoproteins. Selenocysteine lyase (SCL) is an enzyme which decomposes Sec into selenide and alanine, releasing the selenide to be further utilized to synthesize new selenoproteins. Disruption of the selenocysteine lyase gene (

Indexed as

LyasesAmino AcidsAnimalsFemaleMaleMetabolomeMetabolomicsMiceMice, KnockoutSeleniumTranscriptomeAmino AcidsLyasesSeleniumselenocysteine lyaseliverlyasesmetabolomicsseleniumselenocysteinetranscriptomics

Identifiers

PMID31717805
PMCPMC6893568
OpenAlexW2981874532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.