Evidence map›Paper›PMID 31717734›Full record

ArticleToxins2019

A Data-Independent Methodology for the Structural Characterization of Microcystins and Anabaenopeptins Leading to the Identification of Four New Congeners.

Audrey Roy-Lachapelle, Morgan Solliec, Sébastien Sauvé, Christian Gagnon

Abstract read
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Audrey Roy-LachapelleEnvironment and Climate Change Canada, Aquatic Contaminants Research Division, Montréal, QC H2Y 2E5, Canada.ORCID 0000-0002-4896-8323
Morgan SolliecNSERC-Industrial Chair on Drinking Water, CGM Department, École Polytechnique de Montréal, Montréal, QC H3T 1J4, Canada.ORCID 0000-0002-2792-6669
Sébastien SauvéDepartment of Chemistry, Université de Montréal, Montréal, QC H3T 1J4, Canada.ORCID 0000-0001-8584-1690
Christian GagnonEnvironment and Climate Change Canada, Aquatic Contaminants Research Division, Montréal, QC H2Y 2E5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxin-producing cyanobacteria are responsible for the presence of hundreds of bioactive compounds in aquatic environments undergoing increasing eutrophication. The identification of cyanotoxins is still emerging, due to the great diversity of potential congeners, yet high-resolution mass spectrometry (HRMS) has the potential to deepen this knowledge in aquatic environments. In this study, high-throughput and sensitive on-line solid-phase extraction ultra-high performance liquid chromatography (SPE-UHPLC) coupled to HRMS was applied to a data-independent acquisition (DIA) workflow for the suspect screening of cyanopeptides, including microcystin and anabaenopeptin toxin classes. The unambiguous characterization of 11 uncommon cyanopeptides was possible using a characterization workflow through extensive analysis of fragmentation patterns. This method also allowed the characterization of four unknown cyanotoxins ([Leu

Indexed as

Molecular StructureBacterial ToxinsCarcinogensChromatography, LiquidMarine ToxinsMass SpectrometryMicrocystinsMicrocystisPeptides, CyclicSolid Phase ExtractionBacterial ToxinsCarcinogensMarine ToxinsMicrocystinsPeptides, Cyclicanabaenopeptinscyanobacteriacyanotoxinsdata-independent acquisitionLC-HRMSmicrocystinsnon-target screeningstructural characterizationsuspect screening

Identifiers

PMID31717734
PMCPMC6891544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.