Evidence map›Paper›PMID 31717643›Full record

ArticleNutrients2019

Z-ajoene from Crushed Garlic Alleviates Cancer-Induced Skeletal Muscle Atrophy.

Hyejin Lee, Ji-Won Heo, A-Reum Kim, Minson Kweon, Sorim Nam, Jong-Seok Lim, Mi-Kyung Sung, Sung-Eun Kim, Jae-Ha Ryu

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Modification of human metallothioneins by garlic organosulfur compounds, allicin and ajoene: direct effect on zinc homeostasis with relevance to immune regulation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  5. Review
  6. Review
  7. Muscle and Bone Defects in Metastatic Disease.Current osteoporosis reports · 2022
    Review
  8. Inflammation: Roles in Skeletal Muscle Atrophy.Antioxidants (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Corylifol A fromInternational journal of molecular sciences · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hyejin LeeResearch Institute of Pharmaceutical Sciences, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Ji-Won HeoDepartment of Food and Nutrition, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
A-Reum KimDepartment of Food and Nutrition, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Minson KweonResearch Institute of Pharmaceutical Sciences, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Sorim NamDivision of Biological Sciences and Cellular Heterogeneity Research Center, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Jong-Seok LimDivision of Biological Sciences and Cellular Heterogeneity Research Center, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Mi-Kyung SungDepartment of Food and Nutrition, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.
Sung-Eun KimDepartment of Food and Nutrition, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.ORCID 0000-0002-1472-2405
Jae-Ha RyuResearch Institute of Pharmaceutical Sciences, Sookmyung Women's University, Yongsan-Gu, Seoul 04310, Korea.ORCID 0000-0002-6726-2297
Sookmyung Women's University · KR

Funding

National Research Foundation of Korea 2011-0030074National Research Foundation of Korea 2015R1A2A2A01004607National Research Foundation of Korea NRF-2016R1A6A3A11934151National Research Foundation of Korea NRF-2018R1D1A1B07049941Sookmyung Women's University Research Grants 1-1703-2049Sookmyung Women's University Specialization Program Funding 1-201809-6
6 · The paper itself

Abstract

Skeletal muscle atrophy is one of the major symptoms of cancer cachexia. Garlic (

Indexed as

Muscular AtrophyAnimalsCachexiaCell Line, TumorColonic NeoplasmsDisulfidesGarlicHumansMiceMice, Inbred BALB CMuscle DevelopmentMuscle, SkeletalPlant ExtractsProtective AgentsSulfoxidesajoeneDisulfidesPlant ExtractsProtective AgentsSulfoxidesAllium sativumC2C12 cellscancerskeletal muscle atrophyZ-ajoene

Identifiers

PMID31717643
PMCPMC6893518
OpenAlexW2989107146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.