Evidence map›Paper›PMID 31717603›Full record

ArticleJournal of clinical medicine2019

Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study.

Luisa Averdunk, Christina Fitzner, Tatjana Levkovich, David E Leaf, Michael Sobotta, Jil Vieten, Akinobu Ochi, Gilbert Moeckel, Gernot Marx, Christian Stoppe

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Luisa AverdunkDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Christina FitznerDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Tatjana LevkovichDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
David E LeafDivision of Renal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Michael SobottaDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Jil VietenDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Akinobu OchiDepartment of Nephropathology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Gilbert MoeckelDepartment of Nephropathology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Gernot MarxDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Christian StoppeDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
RWTH Aachen University · DEYale University · USBrigham and Women's Hospital · USHeinrich Heine University Düsseldorf · DE

Funding

Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
NIDDK NIH HHS P30 DK079310
6 · The paper itself

Abstract

Acute kidney injury (AKI) is one of the most frequent complications after cardiac surgery and is associated with poor outcomes. Biomarkers of AKI are crucial for the early diagnosis of this condition. Secretory leukocyte protease inhibitor (SLPI) is an alarm anti-protease that has been implicated in the pathogenesis of AKI but has not yet been studied as a diagnostic biomarker of AKI. Using two independent cohorts (development cohort (DC),

Indexed as

acute kidney injurybiomarkerscardiovascular surgerycomplicationsICU

Identifiers

PMID31717603
PMCPMC6912354
OpenAlexW2988054758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.