ArticleJournal of clinical medicine2019
Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Nonpharmacological Treatment of Persistent Postconcussion Symptoms in Adults: A Systematic Review and Meta-analysis and Guideline Recommendation.JAMA network open · 2021Guideline
- Effectiveness of specialized rehabilitation after mild traumatic brain injury: A systematic review and meta-analysis.Journal of rehabilitation medicine · 2021Pooled it
- The impact of persistent post-concussion symptoms and exercise intolerance on patient-specific functioning after mild traumatic brain injury: a biopsychosocial perspective.Journal of rehabilitation medicine · 2026Trial
- Effects of sub-symptom threshold aerobic exercise on persistent postconcussion symptom burden and exercise intolerance: a randomized controlled trial.Physical therapy · 2026Trial
- CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury.The journal of headache and pain · 2022Trial
- Comparing people with persisting post-concussion symptoms from an emergency department-based research sample with patients in a clinical rehabilitation sample: an explorative, retrospective analysis.Journal of rehabilitation medicine · 2026Observational
- The experiences and perspectives of participating in a nature integrative rehabilitation programme when suffering from post-concussion syndrome: responses, gains, and impact from using enriched nature environments as a rehabilitation setting and integrating nature as rehabilitation means.International journal of qualitative studies on health and well-being · 2025Article
- Exploring exercise intolerance in adult patients with persistent post-concussion symptoms after mild traumatic brain injury.Journal of rehabilitation medicine · 2025Article
- Feasibility of Physical Therapy Evaluation Symptom Provocation Tests in Older Adults With Mild Traumatic Brain Injury: Mixed Methods Study.JMIR formative research · 2025Article
- Considering the Effects of Cannabinoids and Exercise on the Brain: A Narrative Review.Sports (Basel, Switzerland) · 2025Review
- Article
- Distinct symptom recoveries based upon highest level of care in patients with sport-related concussion or traumatic brain injury and Glasgow Coma Scale 13-15.Clinical neurology and neurosurgery · 2025Article
- Article
- Subsequent Emergency Department Visits in Geriatric Mild Traumatic Brain Injury: Relationship with Fall, Payor, and Discharge Outcome.Healthcare (Basel, Switzerland) · 2025Article
- Outcomes after Traumatic Brain Injury with and Without Computed Tomography.Journal of neurotrauma · 2025Article
- Current status of neurotrauma management in resource-limited settings.Annals of medicine and surgery (2012) · 2025Review
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Validation Study of Mild Traumatic Brain Injury Case-Identifying Algorithms in French Emergency Departments: High Performance in Children but Limited in Adults.Clinical epidemiology · 2025Article
- Patient satisfaction with rehabilitation services following traumatic brain injury: a quality registry study.Journal of rehabilitation medicine · 2024Article
- Can Long-Term Outcomes of Posttraumatic Headache be Predicted?Current pain and headache reports · 2024Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) at three and six months post-injury. Patients were included through the prospective cohort study: Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI). Patients enrolled with mTBI (Glasgow Coma Scale 13-15) were further differentiated into complicated and uncomplicated mTBI based on the presence or absence of computed tomography abnormalities, respectively. The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) assessed post-concussion symptoms and PCS according to the mapped ICD-10 classification method. The occurrence of post-concussion symptoms and syndrome at both time points was calculated. Chi square tests were used to test for differences between and within groups. Logistic regression was performed to analyse the association between complicated versus uncomplicated mTBI and the prevalence of PCS. Patients after complicated mTBI reported slightly more post-concussion symptoms compared to those after uncomplicated mTBI. A higher percentage of patients after complicated mTBI were classified as having PCS at three (complicated: 46% vs. uncomplicated: 35%) and six months (complicated: 43% vs. uncomplicated 34%). After adjusting for baseline covariates, the effect of complicated versus uncomplicated mTBI at three months appeared minimal: odds ratio 1.25 (95% confidence interval: 0.95-1.66). Although patients after complicated mTBI report slightly more post-concussion symptoms and show higher PCS rates compared to those after uncomplicated mTBI at three and six months, complicated mTBI was only found a weak indicator for these problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.