Evidence map›Paper›PMID 31717318›Full record

ArticleInternational journal of molecular sciences2019

Neutrophil Maturation and Survival Is Controlled by IFN-Dependent Regulation of NAMPT Signaling.

Elena Siakaeva, Ekaterina Pylaeva, Ilona Spyra, Sharareh Bordbari, Benedikt Höing, Cornelius Kürten, Stephan Lang, Jadwiga Jablonska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Regulatory roles of MKP7/DUSP16 in cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elena SiakaevaTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Ekaterina PylaevaTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-3941-9664
Ilona SpyraTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Sharareh BordbariTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-8766-3135
Benedikt HöingTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Cornelius KürtenTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Stephan LangTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Jadwiga JablonskaTranslational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0003-1490-2542
University of Duisburg-Essen · DE

Funding

Deutsche Forschungsgemeinschaft JA 2461/2-1Deutsche Krebshilfe 111647
6 · The paper itself

Abstract

Granulocyte-colony stimulating factor (G-CSF)/nicotinamide phosphoribosyltransferase (NAMPT) signaling has been shown to be crucial for the modulation of neutrophil development and functionality. As this signaling pathway is significantly suppressed by type I interferons (IFNs), we aimed to study how the regulation of neutrophil differentiation and phenotype is altered in IFN-deficient mice during granulopoiesis. The composition of bone marrow granulocyte progenitors and their

Indexed as

Cell DifferentiationSignal TransductionAnimalsApoptosisCell SurvivalGranulocyte Colony-Stimulating FactorGranulocyte Precursor CellsHL-60 CellsHumansInterferonsMice, Inbred C57BLNeutrophil InfiltrationNeutrophilsNicotinamide PhosphoribosyltransferaseReceptor, Interferon alpha-betaGranulocyte Colony-Stimulating FactorIfnar1 protein, mouseInterferonsNicotinamide PhosphoribosyltransferaseReceptor, Interferon alpha-betaapoptosisgranulopoiesisNAMPTneutrophil maturation and survivalneutrophil progenitorstype I interferons

Identifiers

PMID31717318
PMCPMC6888478
OpenAlexW2986453878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.