Evidence map›Paper›PMID 31717266›Full record

ReviewInternational journal of molecular sciences2019

Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels.

Xiaopei Zhang, Wei Wang, Weidong Zhu, Jie Dong, Yingying Cheng, Zujun Yin, Fafu Shen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 529 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
529citing papers in PubMed, 1 pooled it
69.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

529 citing papers in PubMed, 1 synthesis or guideline pooled it, 844 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. The pachytene-specific lncRNANon-coding RNA research · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Methylation marks breast cancer metastasis: The roles of mThe Journal of biological chemistry · 2026
    Review
  19. Review
  20. Review

469 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaopei ZhangState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.
Wei WangState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.ORCID 0000-0002-5705-8591
Weidong ZhuState Key Laboratory of Cotton Biology, Chinese Academy of Agricultural Sciences Cotton Research Institute, Key Laboratory for Cotton Genetic Improvement, Anyang 45500, Henan, China.
Jie DongState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.
Yingying ChengState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.
Zujun YinState Key Laboratory of Cotton Biology, Chinese Academy of Agricultural Sciences Cotton Research Institute, Key Laboratory for Cotton Genetic Improvement, Anyang 45500, Henan, China.
Fafu ShenState Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.ORCID 0000-0003-1977-8712
Shandong Agricultural University · CNCotton Research Institute · CN

Funding

China Major Projects for Transgenic Breeding 2016ZX08005-004National Key Research and Development program of China 2016YFD0101400National Key Research and Development program of China 2018YFD0100303
6 · The paper itself

Abstract

Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.

Indexed as

AnimalsChromatinDNA MethylationGenomeHistonesHumansProtein Processing, Post-TranslationalRNA, Long NoncodingChromatinHistonesRNA, Long NoncodingepigeneticlncRNApost-transcriptionalpost-translational modificationtranscriptionaltranslation

Identifiers

PMID31717266
PMCPMC6888083
OpenAlexW2982711111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.