ArticleJournal of pineal research2020
Two indoleamines are secreted from rat pineal gland at night and act on melatonin receptors but are not night hormones.
Article in Journal of pineal research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Association of melatonin receptor 1 A with litter size in sheep: A review.F1000Research · 2023Review
- Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt's voles (Lasiopodomys brandtii).Microbiome · 2022Article
- Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionAt night, the pineal gland produces the indoleamines, melatonin, N-acetylserotonin (NAS), and N-acetyltryptamine (NAT). Melatonin is accepted as a hormone of night. Could NAS and NAT serve that role too?
methodsConcentration-response measurements with overexpressed human melatonin receptors MT
resultsWe show that NAT and NAS do activate melatonin receptors MT
conclusionBlood levels of NAS and NAT were insufficient to activate peripheral melatonin receptors, and they were invariant, so they could not serve as circulating hormones of night. However, they could instead act in paracrine circadian fashion near the pineal gland or via other higher-affinity receptors.
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Registered trials
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