ArticleSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2020
Characterization of nanofibers for tissue engineering: Chemical mapping by Confocal Raman microscopy.
Article in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Cell alignment on novel polymeric micro-hollow fiber membranes for neural and musculoskeletal tissue engineering.Cell and tissue research · 2026Article
- Design and characterization of anti-microbial novel herbal nanofiber scaffolds for the management of periodontal diseases.Scientific reports · 2025Article
- Spectroscopic Insights into the Localization and Photodynamic Efficacy of Aluminum Tetrasulfonated Phthalocyanine for Colorectal Cancer Therapy.The journal of physical chemistry. B · 2025Article
- Analysis of Chemical Heterogeneity in Electrospun Fibers Through Hyperspectral Raman Imaging Using Open-Source Software.Polymers · 2025Article
- Raman Analysis of Orientation and Crystallinity in HighApplied spectroscopy · 2023Article
- Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV.Vaccines · 2021Article
- Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD).Free radical biology & medicine · 2021Article
- Quantitative label-free imaging of iron-bound transferrin in breast cancer cells and tumors.Redox biology · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Nanofiber scaffolds are used in bioengineering for functional support of growing tissues. To fine tune nanofiber properties for specific applications, it is often necessary to characterize the spatial distribution of their chemical content. Raman spectroscopy is a common tool used to characterize chemical composition of various materials, including nanofibers. In combination with a confocal microscope, it allows simultaneous mapping of both spectral and spatial features of inhomogeneous structures, also known as hyperspectral imaging. However, such mapping is usually performed on microscopic scale, due to the resolution of the scanning system being diffraction limited (about 0.2-0.5 micron, depending on the excitation wavelength). We present an application of confocal Raman microscopy to hyperspectral mapping of nanofibers, where nanoscale features are resolved by means of oversampling and extensive data processing, including Singular Value Decomposition and Classical Least Squares decomposition techniques. Oversampling and data processing facilitated evaluation of the spatial distribution of different chemical components within multi-component nanofibers.
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