Evidence map›Paper›PMID 31715337›Full record

ArticleBone2020

Perlecan/Hspg2 deficiency impairs bone's calcium signaling and associated transcriptome in response to mechanical loading.

Shaopeng Pei, Sucharitha Parthasarathy, Ashutosh Parajuli, Jerahme Martinez, Mengxi Lv, Sida Jiang, Danielle Wu, Shuo Wei, X Lucas Lu, Mary C Farach-Carson and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. A Novel PathogenicFrontiers in neurology · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shaopeng PeiCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
Sucharitha ParthasarathyDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, United States.
Ashutosh ParajuliDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, United States.
Jerahme MartinezCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
Mengxi LvCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
Sida JiangCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
Danielle WuDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, TX 77054, United States.
Shuo WeiCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
X Lucas LuCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States.
Mary C Farach-CarsonDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, TX 77054, United States.
Catherine B Kirn-SafranDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, United States; Department of Biology, Widener University, Chester, PA 19013, United States.
Liyun WangCenter for Biomechanical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States; Department of Biological Sciences, University of Delaware, Newark, DE 19716, United States; Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: lywang@udel.edu.
University of Delaware · USThe University of Texas Health Science Center at Houston · USWidener University · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
Supplement to R01 Titled: Mechanosensing in the Bone Lacunar-Canalicular SystemR01AR054385 · NIAMS · UNIVERSITY OF DELAWARE · PI FARACH-CARSON, MARY C, WANG, LIYUN · 2007 to 2019
$3.8M
NIAMS NIH HHS R01 AR054385NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P30 GM103333
6 · The paper itself

Abstract

Perlecan, a heparan sulfate proteoglycan, acts as a mechanical sensor for bone to detect external loading. Deficiency of perlecan increases the risk of osteoporosis in patients with Schwartz-Jampel Syndrome (SJS) and attenuates loading-induced bone formation in perlecan deficient mice (Hypo). Considering that intracellular calcium [Ca

Indexed as

Calcium SignalingHeparan Sulfate ProteoglycansAnimalsHumansMechanotransduction, CellularMiceTranscriptomeHeparan Sulfate ProteoglycansperlecanER calcium regulatorsintracellular calciumosteocytePerlecanSchwartz-Jampel Syndrome (SJS)tibial loading

Identifiers

PMID31715337
PMCPMC6945981
OpenAlexW2988625363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.