ArticleThe American journal of medicine2020
Risk Factors and Outcomes of Very Young Adults Who Experience Myocardial Infarction: The Partners YOUNG-MI Registry.
Article in The American journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05585138 (Effects of Preoperative Segmental Breathing Exercise on Postoperative Pulmonary Complications in Patients Awaiting Coronary Artery Bypass Graft Surgery), which is not on this map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Preoperative Segmental Breathing Exercise on Postoperative Pulmonary Complications in Patients Awaiting Coronary Artery Bypass Graft Surgery (CABG)
Who cites it
81 citing papers in PubMed, 138 citations in OpenAlex.
- Association of social drivers of health with differential incidence of cardiovascular disease in young adults.American journal of preventive cardiology · 2026Article
- Article
- Exploratory LC-MS/MS-Based Proteomic and Lipidomic Profiling of Plasma Samples from Premature Coronary Artery Disease Patients: A Pilot Study in a South Asian Population.International journal of molecular sciences · 2026Article
- Temporal Trends in Lipid-Lowering Therapy Use and Adherence in Patients With Premature Coronary Artery Disease.Journal of the American Heart Association · 2026Article
- Coronary Computed Tomography and Artificial Intelligence-based Plaque Analysis.Current atherosclerosis reports · 2026Review
- Metabolic risk factors associated with premature myocardial infarction in adults ≤ 35 years: a case-control study.BMC cardiovascular disorders · 2026Article
- Diagnostic challenges in acute coronary syndrome: reconciling the STEMI-NSTEMI and OMI-NOMI paradigms.BMC cardiovascular disorders · 2026Article
- Acute STEMI in a young adult without conventional risk factors: a case report of JAK2-positive essential thrombocythemia.European heart journal. Case reports · 2026Article
- Characteristics and outcomes of type 2 myocardial infarction in sepsis survivors.Frontiers in cardiovascular medicine · 2026Article
- A Rising Threat of Very Young Age Myocardial Infarction.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025Article
- Standard modifiable cardiovascular risk factors and coronary artery disease severity in adults with myocardial infarction ≤ 35.American journal of preventive cardiology · 2025Article
- Clinical, Laboratory and Instrumental Characteristics of Myocardial Infarction in Young Patients Depending on the Prevalence of Coronary Atherosclerosis.Medicina (Kaunas, Lithuania) · 2025Article
- Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction.World journal of cardiology · 2025Review
- Risk factor monitoring, management and use of prevention medicines in those with a history of premature coronary heart disease.Open heart · 2025Article
- Myocardical Infarction in Young Adults: Revisiting Risk Factors and Atherothrombotic Pathways.Medicina (Kaunas, Lithuania) · 2025Review
- Contribution of high BMI to the global burden of cardiovascular disease among young adults aged 20-39 from 1990 to 2021: A systematic analysis for the Global burden of disease study 2021.American journal of preventive cardiology · 2025Article
- Myocardial Infarction in Young Adults: A Case Series and Comprehensive Review of Molecular and Clinical Mechanisms.Biomolecules · 2025Review
- Acute Myocardial Infarction and Diffuse Coronary Artery Disease in a Patient with Multiple Sclerosis: A Case Report and Literature Review.Journal of clinical medicine · 2025Review
- Comparison of Myocardial Function in Young and Old Mice During Acute Myocardial Infarction: A Cardiac Magnetic Resonance Study.Diagnostics (Basel, Switzerland) · 2025Article
- Myocardial Infarction in the Young: Aetiology, Emerging Risk Factors, and the Role of Novel Biomarkers.Journal of cardiovascular development and disease · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDespite significant progress in primary prevention, the rate of myocardial infarction has not decreased in young adults. We sought to compare the risk factor profiles and outcomes between individuals who experienced a first myocardial infarction at a very young (≤40 years) and a young (age 41-50 years) age.
methodsWe evaluated all patients ≤50 years of age admitted with a Type 1 myocardial infarction to 2 large academic hospitals from 2000 to 2016. Risk factors were determined by review of electronic medical records. The primary outcomes of interest were all-cause and cardiovascular mortality.
resultsAmong 2097 consecutive young patients with myocardial infarction, 431 (20.5%) were ≤40 years of age. When compared with their older counterparts, very young patients had similar risk profiles, with the exception of greater substance abuse (17.9% vs 9.3%, P < .001) and less hypertension (37.9% vs 50.9%, P < .001). Spontaneous coronary artery dissection was more prevalent in very young patients (3.1% vs 1.1%, P = .003). Over a median follow-up of 11.2 years, very young myocardial infarction patients had a similar risk of all-cause and cardiovascular mortality.
conclusionsDespite being, on average, 10 years younger and having a lower prevalence of hypertension, very young myocardial infarction patients had similar 1-year and long-term outcomes when compared with those aged 41 to 50 years at the time of their index infarction. Our findings suggest the need for aggressive secondary prevention measures in very young patients who experience a myocardial infarction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.