Evidence map›Paper›PMID 31715094›Full record

ArticleJournal of neurogastroenterology and motility2020

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita J L Leembruggen, Elisa L Hill-Yardin, René Koopman, Joel C Bornstein and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of neurogastroenterology and motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Review
  6. Caveolin and NOS in the Development of Muscular Dystrophy.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kristy SwiderskiCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
Rebecka BindonCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
Jennifer TrieuCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
Timur NaimCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
Shana SchokmanEnteric Nervous System Laboratory, Department of Physiology, The University of Melbourne, Australia.
Mathusi SwaminathanEnteric Nervous System Laboratory, Department of Physiology, The University of Melbourne, Australia.
Anita J L LeembruggenEnteric Nervous System Laboratory, Department of Physiology, The University of Melbourne, Australia.
Elisa L Hill-YardinEnteric Nervous System Laboratory, Department of Physiology, The University of Melbourne, Australia.
René KoopmanCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
Joel C BornsteinEnteric Nervous System Laboratory, Department of Physiology, The University of Melbourne, Australia.
Gordon S LynchCentre for Muscle Research, Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Australia.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsPatients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from dysregulated nitric oxide production. Compounds increasing neuronal nitric oxide synthase expression and/or activity could improve GI dysfunction and enhance quality of life for dystrophic patients. We used video imaging and spatiotemporal mapping to identify GI dysfunction in

methodsFour-week-old male C57BL/10 and

resultsST mapping identified increased contraction number in the mid and distal colon of

conclusionsGI dysfunction in Duchenne muscular dystrophy has been sadly neglected as an issue affecting quality of life. ST mapping identified regional GI dysfunction in the

Indexed as

ArgininecolonDuchenneGastrointestinal diseasesMuscular dystrophyNitric oxide synthase type I

Identifiers

PMID31715094
PMCPMC6955187
OpenAlexW2986604560

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.