ArticleTransboundary and emerging diseases2020
The pulmonary virome, bacteriological and histopathological findings in bovine respiratory disease from western Canada.
Article in Transboundary and emerging diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Development of an influenza D virus with an eight- or nine-segment genome.Scientific reports · 2026Article
- A Comprehensive Review: Molecular Diagnostics and Multi-Omics Approaches to Understanding Bovine Respiratory Disease.Veterinary sciences · 2025Review
- Respiratory Bacteria and Antimicrobial Resistance Genes Detected by Long-Read Metagenomic Sequencing Following Feedlot Arrival, Subsequent Treatment Risk and Phenotypic Resistance in Feedlot Calves.Antibiotics (Basel, Switzerland) · 2025Article
- Isolation, Pathogenicity and Genomic Analysis ofMicroorganisms · 2025Article
- Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.Frontiers in veterinary science · 2025Article
- Prevalences of respiratory viruses and bacteria in Western Canadian commercial feedlot calves detected using a single metagenomic sequencing protocol vary during the first two weeks of arrival and by age group.Frontiers in veterinary science · 2025Article
- Discovery and characterization of BRBV-sheep virus in nasal swabs from domestic sheep in China.Frontiers in cellular and infection microbiology · 2024Article
- Article
- Postmortem diagnoses and factors influencing diagnoses in captive white-tailed deer in Wisconsin, 2009-2021.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Association of ovine gammaherpesvirus 2 with an outbreak of acute respiratory disease in dairy cattle.Scientific reports · 2023Article
- Determining Frequency of Common Pulmonary Gross and Histopathological Findings in Feedyard Fatalities.Veterinary sciences · 2023Article
- Generation of a recombinant temperature-sensitive influenza D virus.Scientific reports · 2023Article
- Characterisation of the Upper Respiratory Tract Virome of Feedlot Cattle and Its Association with Bovine Respiratory Disease.Viruses · 2023Article
- Possible Association of Bovine Gammaherpesvirus 6 with Pulmonary Disease in a Cow.Animals : an open access journal from MDPI · 2023Article
- Development of a colloidal gold immunochromatographic strip with enhanced signal for the detection of bovine parvovirus.Frontiers in microbiology · 2023Article
- Assessment of Rapid MinION Nanopore DNA Virus Meta-Genomics Using Calves Experimentally Infected with Bovine Herpes Virus-1.Viruses · 2022Article
- Seminal and histopathological alterations in bucks challenged with Mannheimia haemolytica serotype a2 and its LPS endotoxin.Tropical animal health and production · 2022Article
- HoBi-like pestivirus in 2 cases of fatal respiratory disease of feedlot cattle in Argentina.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Bovine respiratory microbiota of feedlot cattle and its association with disease.Veterinary research · 2022Review
- Genetic characterization of upper respiratory tract virome from nonvaccinated Egyptian cow-calf operations.PloS one · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The aetiology and pathogenesis of bovine respiratory disease (BRD) are complex and involve the interplay of infectious agents, management and environmental factors. Previous studies of BRD focused on ante-mortem samples from the upper respiratory tract and identified several unconventional viruses. The lung, however, is the primary location where significant BRD lesions are usually found and is a common post-mortem diagnostic specimen. In this study, results of high-throughput virome sequencing, bacterial culture, targeted real-time PCR and histological examination of 130 bovine pneumonic lungs from western Canadian cattle were combined to explore associations of microorganisms with different types of pneumonia. Fibrinous bronchopneumonia (FBP) was the predominant type of pneumonia (46.2%, 60/130) and was associated with the detection of Mannheimia haemolytica. Detection of Histophilus somni and Pasteurella multocida was associated with suppurative bronchopneumonia (SBP) and concurrent bronchopneumonia and bronchointerstitial pneumonia (BP&BIP), respectively. Sixteen viruses were identified, of which bovine parvovirus 2 (BPV2) was the most prevalent (11.5%, 15/130) followed by ungulate tetraparvovirus 1 (UTPV1, 8.5%, 11/130) and bovine respiratory syncytial virus (BRSV, 8.5%, 11/130). None of these viruses, however, were significantly associated with a particular type of pneumonia. Unconventional viruses such as influenza D virus (IDV) and bovine rhinitis B virus (BRBV) were detected, although sparsely, consistent with our previous findings in upper respiratory tract samples. Taken together, our results show that while virus detection in post-mortem lung samples is of relatively little diagnostic value, the strong associations of H. somni and M. haemolytica with SBP and FBP, respectively, indicate that histopathology can be useful in differentiating bacterial aetiologies.
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