ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020
Hypertension, but not body mass index, is predictive of increased pancreatic lipid content and islet dysfunction.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Relationship of fat in the pancreas with cardiovascular disease: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Quantifying Pancreatic Fat Using a Free-Breathing Acquisition in Adults With Obesity Undergoing Diet-Induced Weight Loss-Results From the LION Study.NMR in biomedicine · 2026Trial
- Intra-Pancreatic Fat Deposition Versus Hepatic Fat in Relation to Incident Heart Failure: A Prospective Cohort Analysis.Reviews in cardiovascular medicine · 2026Article
- Aetiology of type 2 diabetes: an experimental medicine odyssey.Diabetologia · 2025Review
- Adherence to the dietary approaches to stop hypertension (DASH) and risk of pancreatic steatosis.Journal of health, population, and nutrition · 2024Article
- Correlation between Pancreatic Fat Deposition and Metabolic Syndrome: Relationships with Location in the Pancreas and Sex.Internal medicine (Tokyo, Japan) · 2024Article
- Donor- and isolation-related predictive factors ofFrontiers in endocrinology · 2024Article
- Fatty infiltration of the pancreas: a systematic concept analysis.Frontiers in medicine · 2023Review
- Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level.Cardiovascular diabetology · 2022Article
- A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment.Scientific reports · 2022Article
- Intra-pancreatic fat deposition: bringing hidden fat to the fore.Nature reviews. Gastroenterology & hepatology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Pancreatic steatosis is thought to be a negative risk factor for pancreas transplant outcomes. Despite considering donor body mass index (BMI) and the visualization of intercalated fat as indicators of donor pancreas lipid content, transplant surgeons do not use a quantitative method to directly measure steatosis when deciding to transplant a pancreas. In this study, we used nondiabetic human pancreata donated for research to measure the pancreatic and islet-specific lipid content to determine which clinical markers correlate best with lipid content. Interestingly, we found that BMI and age correlate with increased pancreatic lipid content (Panc-LC) in men, but not women. Our findings further suggest that total Panc-LC correlates with an increase in islet lipid content for both men and women. We noted that pancreata donated from individuals with a history of hypertension have increased Panc-LC independent of donor BMI or sex. Moreover, we identify hypertension as a risk factor for reduced islet function after islet isolation. Together, our findings emphasize differences in pancreas graft quality related to pancreatic and islet lipid content, which may not be predicted by assessing BMI alone but may be influenced by a donor history of hypertension.
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