ArticlePloS one2019
Effects of insulin signaling on mouse taste cell proliferation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- GLP-1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- Expression ofbioRxiv : the preprint server for biology · 2026Article
- Effects of high-fat and low-calcium diets on the structure of filiform and fungiform tongue papillae in rats.Scientific reports · 2025Article
- Pig Taste Cell-derived Organoids Synthesize Insulin.Endocrinology · 2025Article
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds.Journal of neurochemistry · 2025Article
- Organoids in the oral and maxillofacial region: present and future.International journal of oral science · 2024Review
- Determining the sweet detection threshold of COVID-19 patients during infection and recovery periods.PloS one · 2024Article
- Smell, taste and food habits changes along body mass index increase: an observational study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Observational
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- Ascl1-expressing cell differentiation in initially developed taste buds and taste organoids.Cell and tissue research · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Article
- Amino Acid-Induced Impairment of Insulin Signaling and Involvement of G-Protein Coupling Receptor.Nutrients · 2021Review
- Western Diet Induced Remodelling of the Tongue Proteome.Proteomes · 2021Article
- A Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies.Chemical senses · 2021Review
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?Diabetes & metabolism journal · 2020Review
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expression of IR mRNA and protein in mouse taste bud cells in vivo and explored its function ex vivo in organoids, using RT-PCR, immunohistochemistry, and quantitative PCR. In mouse taste tissue, IR was expressed broadly in taste buds, including in type II and III taste cells. With using 3-D taste bud organoids, we found insulin in the culture medium significantly decreased the number of taste cell and mRNA expression levels of many taste cell genes, including nucleoside triphosphate diphosphohydrolase-2 (NTPDase2), Tas1R3 (T1R3), gustducin, carbonic anhydrase 4 (CA4), glucose transporter-8 (GLUT8), and sodium-glucose cotransporter-1 (SGLT1) in a concentration-dependent manner. Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) signaling, diminished insulin's effects and increase taste cell generation. Altogether, circulating insulin might be an important regulator of taste cell growth and/or proliferation via activation of the mTOR pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.