Evidence map›Paper›PMID 31714690›Full record

Trial reportAnnals of clinical and translational neurology2019

Plasma urate concentrations and possible REM sleep behavior disorder.

Yun Shen, Junjuan Li, Michael Schwarzschild, Milena Pavlova, Songbin He, Alberto Ascherio, Shouling Wu, Liufu Cui, Xiang Gao

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neurochemical Features of Rem Sleep Behaviour Disorder.Journal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Yun ShenDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Junjuan LiDepartment of Nephrology, Kailuan General Hospital, Tangshan, China.
Michael SchwarzschildDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Milena PavlovaDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Songbin HeDepartment of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China.
Alberto AscherioDepartment of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Shouling WuDepartment of Cardiology, Kailuan General Hospital, Tangshan, China.
Liufu CuiDepartment of Rheumatology, Kailuan General Hospital, Tangshan, China.
Xiang GaoDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.ORCID 0000-0003-2617-6509
Kailuan General Hospital · CNBrigham and Women's Hospital · USHarvard University · USMassachusetts Department of Public Health · USPennsylvania State University · USSoochow University · CNWenzhou Medical University · CN

Funding

college of health and human development and the department of nutritional sciences Penn State UniversityInstitute for CyberScience Seed Grant Program Penn State UniversityJiangsu Provincial social development projects BE2018658National Key R&D Program of China 2017YFC0909100
6 · The paper itself

Abstract

objectiveTo examine how urate concentrations are related to the risk of having possible REM sleep behavior disorder (pRBD) in a community-based cohort.

methodsThe study included 12,923 Chinese adults of the Kailuan Study, free of Parkinson disease (PD) and dementia. Plasma urate concentrations were measured in 2006, 2008, and 2010. Cumulative average urate concentration was used as primary exposure. In 2012, we determined pRBD status using a validated RBD questionnaire-Hong Kong (RBDQ-HK). Logistic regression analysis was performed to estimate the association between urate concentrations during 2006-2010 and odds of having pRBD in 2012 or pRBD case with symptom onset within 1 year.

resultsHigher average urate concentrations were associated with a lower odds of pRBD (P-trend <0.001). The adjusted odds ratio (OR), for the highest versus lowest urate quintiles, was 0.43 (95% confidence intervals (CIs) 0.32-0.57). Significant association was consistently observed when we examined the association of a single urate assessment (2006 or 2010) or the rate of change in urate concentrations during 2006-2010 with pRBD (P-trend <0.001 for all). However, restricting to pRBD onset during 2011-2012, we observed a nonsignificant trend between high urate concentration and high odds of pRBD (P-trend = 0.09).

interpretationHigher average urate concentrations were associated with a lower likelihood of having pRBD, but not new-onset pRBD. Because of its observational study design, the result should be interpreted with caution due to the possibility of residual confounding.

Indexed as

FemaleHumansMaleMiddle AgedREM Sleep Behavior DisorderUric AcidUric Acid

Identifiers

PMID31714690
PMCPMC6917330
OpenAlexW2986111837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.