ArticleThe Laryngoscope2020
Peak Sinus Pressures During Sneezing in Healthy Controls and Post-Skull Base Surgery Patients.
Article in The Laryngoscope, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Exploring E-Vape Aerosol Penetration into Paranasal Sinuses: Insights from Patient-Specific Models.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies.Diagnostics (Basel, Switzerland) · 2025Review
- Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus.Drug delivery and translational research · 2024Article
- A technical feasibility study on adaptation of a microsurgical robotic system to an intraoperative complication management in dental implantology: perforated Schneiderian membrane repair using SymaniJournal of robotic surgery · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisPatients are frequently advised to sneeze with an open mouth and avoid nose-blowing following an endoscopic endonasal approache (EEA) to the skull base, despite a lack of quantitative evidence. This study applies computational fluid dynamics (CFD) to quantify sinus pressures along the skull base during sneezing. STUDY
designCase-control series.
methodsComputed tomography or magnetic resonance imaging scans of four post-EEA patients and four healthy controls were collected and analyzed utilizing CFD techniques. A pressure drop of 6,000 Pa was applied to the nasopharynx based on values in the literature to simulate expiratory nasal airflow during sneezing. Peak pressures along the skull base in frontal, ethmoid, and sphenoid sinuses were collected.
resultsSignificant increases in skull base peak pressure was observed during sneezing, with significant individual variations from 2,185 to 5,685 Pa. Interestingly, healthy controls had significantly higher pressures compared to post-EEA patients (5179.37 ± 198.42 Pa vs. patients 3,347.82 ± 1,472.20 Pa, P < .05), which could be related to higher anterior nasal resistance in unoperated healthy controls (0.44 ± 0.22 vs. 0.31 ± 0.16 Pa/mL/sec for patients, P = .38). The sinus pressure buildup may be due to airway resistance functioning as a valve preventing air from being released quickly. Supporting this theory, there was a strong correlation (r = 0.82) between peak skull base pressure and the ratio of anterior resistance to total resistance. Within-subject variation in pressures between different skull base regions was much lower (average = ~5%).
conclusionsThis study provided the first quantitative analysis of air pressure along the skull base during sneezing in post-EEA patients through CFD, suggesting that pressure buildup may depend on individual anatomy. LEVEL OF EVIDENCE: 3b Laryngoscope, 130:2138-2143, 2020.
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