ArticleeLife2019
DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders.Frontiers in pharmacology · 2025Review
- A mortality timer based on nucleolar size triggers nucleolar integrity loss and catastrophic genomic instability.Nature aging · 2024Article
- Reliable replicative lifespan determination of yeast with a single-channel microfluidic chip.Biology open · 2024Article
- Current insights into transcriptional role(s) for the nutraceuticalFrontiers in nutrition · 2024Review
- Article
- Determining growth rates from bright-field images of budding cells through identifying overlaps.eLife · 2023Article
- Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes.Nature reviews. Molecular cell biology · 2023Review
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- Article
- Article
- A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors.Journal of fungi (Basel, Switzerland) · 2021Review
- Article
- A new mechanistic insight into fate decisions during yeast cell aging process.Mechanisms of ageing and development · 2021Article
- Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.Nature communications · 2021Article
- Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory DeficientG3 (Bethesda, Md.) · 2020Article
- Article
- Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance.Journal of hematology & oncology · 2020Review
- A programmable fate decision landscape underlies single-cell aging in yeast.Science (New York, N.Y.) · 2020Article
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Genome instability is a hallmark of aging and contributes to age-related disorders such as cancer and Alzheimer's disease. The accumulation of DNA damage during aging has been linked to altered cell cycle dynamics and the failure of cell cycle checkpoints. Here, we use single cell imaging to study the consequences of increased genomic instability during aging in budding yeast and identify striking age-associated genome missegregation events. This breakdown in mitotic fidelity results from the age-related activation of the DNA damage checkpoint and the resulting degradation of histone proteins. Disrupting the ability of cells to degrade histones in response to DNA damage increases replicative lifespan and reduces genomic missegregations. We present several lines of evidence supporting a model of antagonistic pleiotropy in the DNA damage response where histone degradation, and limited histone transcription are beneficial to respond rapidly to damage but reduce lifespan and genomic stability in the long term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.