ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Structural brain abnormalities in patients with psychogenic nonepileptic seizures.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Consequences of Acute Presentations of Functional Neurological Disorders in Neuro-Oncology Patients: Case Series and Systematic Review.Brain and behavior · 2025Pooled it
- Proposed criteria of levels of evidence for co-occurring epilepsy in people with functional/dissociative seizures.Epilepsia · 2026Article
- MRI findings in patients with psychogenic non-epileptic seizures: Prevalence, distribution, and classification of the findings. A single tertiary epilepsy center experience.Epilepsia open · 2025Article
- Are brain MRI abnormalities associated with the semiology of functional seizures?Brain and behavior · 2023Article
- DDESVSFS: A simple, rapid and comprehensive screening tool for the Differential Diagnosis of Epileptic Seizures VS Functional Seizures.Epilepsy research · 2021Article
- Sex Effects on Coping, Dissociation, and PTSD in Patients With Non-epileptic Seizures.Current psychiatry reports · 2020Review
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Abstract
objectivesWe assessed the relationship between the clinical features of patients with psychogenic nonepileptic seizures (PNES) and referrals for brain imaging tests. We also hypothesized that some clinical factors might be associated with structural brain imaging abnormalities in these patients.
methodsIn this retrospective study, patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center, Iran, from 2008 until 2019, were studied.
resultsOne hundred thirty-two patients had a brain magnetic resonance imaging (MRI) study available. Forty-seven patients (36%) had abnormal finding(s) in their MRI. Age (odds ratio = 1.040, p = 0.02), and comorbid epilepsy (odds ratio = 3.006, p = 0.005) were significantly associated with having an abnormal brain MRI. In a subanalysis, we excluded the patients with comorbid epilepsy (46 patients). From the remaining 86 patients (with PNES only), 23 patients (26.7%) had abnormal findings on their MRIs. Common epileptogenic structural brain abnormalities (e.g., tumors, mesial temporal sclerosis, encephalomalacia, and developmental anomalies) were common in patients with comorbid PNES and epilepsy (in 19 out of 46 patients; 41%), but not in those with PNES only (in 4 out of 86 patients; 5%) (p = 0.00001).
conclusionWhile the evidence is convergent on the relatively high prevalence of structural brain abnormalities in patients with PNES, the data so far is suboptimal. In order to investigate the significance of structural brain abnormalities in the development of PNES, future well-designed multicenter studies, which include a large number of patients with a unified methodology of imaging, are desirable.
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