Evidence map›Paper›PMID 31713751›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa.

Ebru N Cetin, Osman Parca, Hasan Samed Akkaya, Gökhan Pekel

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Structural evaluation in inherited retinal diseases.The British journal of ophthalmology · 2021
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ebru N CetinDepartment of Ophthalmology, Pamukkale University, Göz Hastalıkları AD, Kınıklı Kampüsü, Kınıklı, Denizli, Turkey. cetin.ebru@gmail.com.ORCID http://orcid.org/0000-0003-1327-0539
Osman ParcaDepartment of Ophthalmology, Pamukkale University, Göz Hastalıkları AD, Kınıklı Kampüsü, Kınıklı, Denizli, Turkey.
Hasan Samed AkkayaDepartment of Ophthalmology, Pamukkale University, Göz Hastalıkları AD, Kınıklı Kampüsü, Kınıklı, Denizli, Turkey.
Gökhan PekelDepartment of Ophthalmology, Pamukkale University, Göz Hastalıkları AD, Kınıklı Kampüsü, Kınıklı, Denizli, Turkey.
Pamukkale University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the association of retinal biomarkers with the choroidal parameters in retinitis pigmentosa (RP).

methodsThis prospective study included 69 eyes of 36 patients with RP. Choroidal vascularity index (CVI) was defined as the ratio of luminal area to stromal area after binarization on EDI-OCT images. Choroidal thickness (CT); peripapillary CT, the disruptions of the ellipsoid zone (EZ) and external limiting membrane (ELM); and the existence of disorganization of the retinal inner layers (DRIL) and epiretinal membrane (ERM) in central 1000 μm were noted.

resultsHaving DRIL and the disruption of EZ and ELM was significantly associated with higher CVI (p < 0.001, p = 0.001, and p = 0.002 respectively) and lower peripapillary CT in temporal sector (p = 0.031, p = 0.012, and p = 0.043 respectively). Having ERM, the disruption of EZ and ELM was significantly associated with lower visual acuity (VA) (p = 0.044, p < 0.001, and p < 0.001 respectively). The eyes with ERM had significantly lower peripapillary retinal nerve fiber thickness (pRNFLT) (p = 0.040). The mean peripapillary CT significantly and positively correlated with the temporal, nasal, superonasal, and the mean pRNFLT (r = 0.258, p = 0.036, r = 0.252, p = 0.041, r = 0.260, p = 0.035, r = 0.280, p = 0.023 respectively). VA did not significantly correlate with CT, peripapillary CT, or CVI (p > 0.05).

conclusionThe disruption outer retinal segment integrity was significantly associated with higher CVI and lower peripapillary CT in temporal segment. ERM and disruption of ELM and EZ were associated with worse VA. VA did not significantly correlate with CT, peripapillary CT, or CVI.

Indexed as

AdultChoroidFemaleFluorescein AngiographyFundus OculiHumansMaleProspective StudiesRetinal VesselsRetinitis PigmentosaSeverity of Illness IndexTomography, Optical CoherenceVisual AcuityBinarization methodChoroidal thicknessChoroidal vascularity indexDRILEllipsoid zoneEpiretinal membraneExternal limiting membranePeripapillary choroidal thicknessRetinal nerve fiber layerRetinitis pigmentosa

Identifiers

PMID31713751
OpenAlexW2985995945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.