Evidence map›Paper›PMID 31713667›Full record

ArticleNeuroradiology2020

Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study.

Henrik Gensicke, James W Evans, Fahad S Al Ajlan, Dar Dowlatshahi, Mohamed Najm, Ana L Calleja, Josep Puig, Sung-lI Sohn, Seong H Ahn, Alexandre Y Poppe and 11 more

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Henrik GensickeCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. henrik.gensicke@usb.ch.ORCID http://orcid.org/0000-0002-0949-2422
James W EvansCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Fahad S Al AjlanCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dar DowlatshahiUniversity of Ottawa, Ottawa, Ontario, Canada.
Mohamed NajmCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ana L CallejaUniversidad de Valladolid, Valladolid, Spain.
Josep PuigDr Josep Trueta University Hospital, Girona, Spain.
Sung-lI SohnDepartment of Neurology, Brain Research Institute, Keimyung University School of Medicine, Daegu, Republic of Korea.
Seong H AhnDepartment of Neurology, Chosun University School of Medicine, Gwangju, Republic of Korea.
Alexandre Y PoppeCentre Hospitalier de l'Université de Montréal, University of Montréal, Montreal, Québec, Canada.
Robert MikulikInternational Clinical Research Center, Department of Neurology, St Ann's University Hospital, Masaryk University, Brno, Czech Republic.
Negar AsdaghiMiller School of Medicine, University of Miami, Miami, Florida, USA.
Thalia S FieldUniversity of British Columbia, Vancouver, British Columbia, Canada.
Albert JinQueen's University Kingston, Ontario, Canada.
Talip AsilBezmialem Vakif Univesitesi Noroloji, Istanbul, Turkey.
Jean-Martin BoulangerCharles LeMoyne Hospital, University of Sherbrooke, Greenfield Park, Canada.
Michael D HillCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Mayank GoyalCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Andrew M DemchukCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Bijoy K MenonCalgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
INTERRSeCT Investigators

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P300PB_161071
6 · The paper itself

Abstract

purposeTo compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase.

methodsPatients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (ΔHUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC).

resultsFour hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HU

conclusionSimple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.

Indexed as

AgedAged, 80 and overBayes TheoremComputed Tomography AngiographyFemaleFibrinolytic AgentsHumansIntracranial ThrombosisMaleMiddle AgedProspective StudiesTissue Plasminogen ActivatorTomography, X-Ray ComputedFibrinolytic AgentsTissue Plasminogen ActivatorAcute ischemic strokeCTANCCTRecanalization therapiesThrombus permeability

Identifiers

PMID31713667

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.