Evidence map›Paper›PMID 31713652›Full record

ArticlePediatric cardiology2020

Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

Marijke H van der Meulen, Susanna den Boer, Gideon J du Marchie Sarvaas, Nico A Blom, Arend D J Ten Harkel, Hans M P J Breur, Lukas A J Rammeloo, Ronald Tanke, Willem A Helbing, Eric Boersma and 1 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Marijke H van der MeulenDepartment of Pediatric Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Susanna den BoerDepartment of Pediatric Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Gideon J du Marchie SarvaasDepartment of Pediatric Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nico A BlomDepartment of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Arend D J Ten HarkelDepartment of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Hans M P J BreurDepartment of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Lukas A J RammelooDepartment of Pediatric Cardiology, Free University Medical Center, Amsterdam, The Netherlands.
Ronald TankeDepartment of Pediatric Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Willem A HelbingDepartment of Pediatric Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Eric BoersmaDepartment of Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Michiel DalinghausDepartment of Pediatric Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. m.dalinghaus@erasmusmc.nl.
Erasmus MC · NLLeiden University Medical Center · NLRadboud University Medical Center · NLAcademic Medical Center · NLUniversity of Groningen · NLWilhelmina Children's Hospital · NL

Funding

Hartstichting 2013T087
6 · The paper itself

Abstract

A single 6-min walk test (6MWT) can be used to identify children with dilated cardiomyopathy (DCM) with a high risk of death or heart transplantation. To determine if repeated 6MWT has added value in addition to a single 6MWT in predicting death or heart transplantation in children with DCM. Prospective multicenter cohort study including ambulatory DCM patients ≥ 6 years. A 6MWT was performed 1 to 4 times per year. The distance walked was expressed as percentage of predicted (6MWD%). We compared the temporal evolution of 6MWD% in patients with and without the study endpoint (SE: all-cause death or heart transplantation), using a linear mixed effects model. In 57 patients, we obtained a median of 4 (IQR 2-6) 6MWTs per patient during a median of 3.0 years of observation (IQR 1.5-5.1). Fourteen patients reached a SE (3 deaths, 11 heart transplantations). At any time during follow-up, the average estimate of 6MWD% was significantly lower in patients with a SE compared to patients without a SE. In both patients groups, 6MWD% remained constant over time. An absolute 1% lower 6MWD% was associated with an 11% higher risk (hazard) of the SE (HR 0.90, 95% CI 0.86-0.95 p < 0.001). Children with DCM who died or underwent heart transplantation had systematically reduced 6MWD%. The performance of all patients was stable over time, so repeated measurement of 6MWT within this time frame had little added value over a single test.

Indexed as

Walk TestAdolescentCardiomyopathy, DilatedChildFemaleHeart TransplantationHumansMaleProspective StudiesRisk AssessmentTime Factors6MWTDilated cardiomyopathyHeart failurePediatric cardiologyRisk factors

Identifiers

PMID31713652
PMCPMC7072046
OpenAlexW2986143797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.