Evidence map›Paper›PMID 31713047›Full record

ArticleJournal of gastrointestinal cancer2020

Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews.

Mauro Podda, Giulia Ferraro, Salomone Di Saverio, Alessandro Cois, Oreste Nardello, Gaetano Poillucci, Marco Vito Marino, Adolfo Pisanu

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Article in Journal of gastrointestinal cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mauro PoddaDepartment of Surgery, Cagliari University Hospital "D. Casula", University of Cagliari, SS 554, Km 4,500, 09042, Cagliari, Monserrato, Italy. mauropodda@ymail.com.ORCID http://orcid.org/0000-0001-9941-0883
Giulia FerraroDepartment of Surgery, Cagliari University Hospital "D. Casula", University of Cagliari, SS 554, Km 4,500, 09042, Cagliari, Monserrato, Italy.
Salomone Di SaverioDepartment of Surgery, Cambridge Colorectal Unit, Addenbrooke's Hospital NHS Foundation Trust, University of Cambridge, Cambridge, UK.
Alessandro CoisDepartment of Surgery, Cagliari University Hospital "D. Casula", University of Cagliari, SS 554, Km 4,500, 09042, Cagliari, Monserrato, Italy.
Oreste NardelloDepartment of Surgery, Cagliari University Hospital "D. Casula", University of Cagliari, SS 554, Km 4,500, 09042, Cagliari, Monserrato, Italy.
Gaetano PoillucciDepartment of Surgery "Paride Stefanini", Policlinico Universitario Umberto I, Sapienza University, Rome, Italy.
Marco Vito MarinoDepartment of General Surgery, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain.
Adolfo PisanuDepartment of Surgery, Cagliari University Hospital "D. Casula", University of Cagliari, SS 554, Km 4,500, 09042, Cagliari, Monserrato, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLittle is known about the sporadic coincidence of gastrointestinal stromal tumors (GISTs) with second primary tumors (SPTs). The aim of this study is to clarify if there is a clinicopathologic correlation responsible for the synchronous or metachronous occurrence of SPTs in GIST patients.

methodsWe carried out a single-center, retrospective analysis on patients with GISTs surgically treated at our institution from January 2019 to June 2019. Two groups of patients were identified: isolated GIST (group A) and GIST associated with SPT (group B). A meta-review was conducted with the aim to examine the published systematic reviews that included studies assessing the SPT risk in GIST patients.

resultsThirty-nine patients were surgically treated for GIST during the study period, with seven (17.9%) of them having other SPTs. SPTs were most frequent in the colon. Group A patients had a lower mean age at initial diagnosis (56.8 ± 15.2 vs. 73.4 ± 16.6, P = 0.012). No statistically significant difference was found between the two groups in terms of tumor location, mitotic index, Ki-67 expression, risk classification, and imatinib therapy. The overview showed that the cumulative prevalence rate of SPTs ranged from 9.3 to 18.0%. SPTs were more frequent in the gastrointestinal tract (37.9-95.0%), followed by the genitourinary tract.

conclusionGIST patients under our care experienced a 17.9% overall risk of developing SPTs with different histology. When comparing patients with isolated GIST and patients with GIST and SPT, age was the only variable significantly related to the development of other neoplasms. However, the potential non-random association and causal relationship between GISTs and SPTs remain to be investigated.

Indexed as

Gastrointestinal Stromal TumorsSystematic Reviews as TopicAgedDigestive System Surgical ProceduresFemaleFollow-Up StudiesGastrointestinal NeoplasmsHumansMaleMiddle AgedNeoplasms, Second PrimaryPrognosisRetrospective StudiesAssociated neoplasmsGastrointestinal stromal tumorsOverview of systematic reviewsSecondary primary tumorsSynchronous malignancies

Identifiers

PMID31713047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.