Evidence map›Paper›PMID 31712968›Full record

ArticlePsychopharmacology2020

Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.

Erin M Rock, Samantha M Ayoub, Cheryl L Limebeer, Alexia Gene, Kiri L Wills, Marieka V DeVuono, Reem Smoum, Vincenzo Di Marzo, Aron H Lichtman, Raphael Mechoulam and 1 more

Abstract read
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In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  10. Frontiers in synaptic neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Erin M RockDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Samantha M AyoubDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Cheryl L LimebeerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Alexia GeneDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Kiri L WillsDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Marieka V DeVuonoDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Reem SmoumInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
Vincenzo Di MarzoInstitute of Biomolecular Chemistry, Endocannabinoid Research Group, Consiglio Nazionale delle Richerche, Pozzuli, Naples, Italy.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Raphael MechoulamInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
Linda A ParkerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. parkerl@uoguelph.ca.ORCID http://orcid.org/0000-0002-3494-9754
University of Guelph · CAHebrew University of Jerusalem · ILUniversité Laval · CAVirginia Commonwealth University Medical Center · US

Funding

Institute of Neurosciences, Mental Health and Addiction 388239Natural Sciences and Engineering Research Council of Canada 03629
6 · The paper itself

Abstract

rationaleAcute naloxone-precipitated morphine withdrawal (MWD) produces a conditioned place aversion (CPA) in rats even after one or two exposures to high-dose (20 mg/kg, sc) morphine followed 24-h later by naloxone (1 mg/kg, sc). However, the somatic withdrawal reactions produced by acute naloxone-precipitated MWD in rats have not been investigated. A recently discovered fatty acid amide, N-oleoylglycine (OlGly), which has been suggested to act as a fatty acid amide hydrolase (FAAH) inhibitor and as a peroxisome proliferator-activated receptor alpha (PPARα) agonist, was previously shown to interfere with a naloxone-precipitated MWD-induced CPA in rats.

objectivesThe aims of these studies were to examine the somatic withdrawal responses produced by acute naloxone-precipitated MWD and determine whether OlGly can also interfere with these responses.

resultsHere, we report that following two exposures to morphine (20 mg/kg, sc) each followed by naloxone (1 mg/kg, sc) 24 h later, rats display nausea-like somatic reactions of lying flattened on belly, abdominal contractions and diarrhea, and display increased mouthing movements and loss of body weight. OlGly (5 mg/kg, ip) interfered with naloxone-precipitated MWD-induced abdominal contractions, lying on belly, diarrhea and mouthing movements in male Sprague-Dawley rats, by both a cannabinoid 1 (CB

conclusionThese results suggest that the aversive effects of acute naloxone-precipitated MWD reflect nausea, which is suppressed by OlGly.

Indexed as

AnimalsFemaleGlycineMaleMedically Unexplained SymptomsMorphineMorphine DependenceNaloxoneNarcotic AntagonistsNauseaOleic AcidsRatsRats, Sprague-DawleyShrewsSubstance Withdrawal SyndromeGlycineMorphineNaloxoneNarcotic AntagonistsN-oleoylglycineOleic AcidsAcute naloxone-precipitated morphine withdrawalCB1GapingNauseaN-oleoylglycinePPARαRatsSomatic MWD

Identifiers

PMID31712968
OpenAlexW2988111629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.