ArticleEuropean radiology2020
Diagnostic performance of tomoelastography of the liver and spleen for staging hepatic fibrosis.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Application of Magnetic Resonance Imaging in Liver Biomechanics: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three-Dimensional MR Elastography With Same-Day Biopsy in a Prospective Cohort.Journal of magnetic resonance imaging : JMRI · 2026Article
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration.Magnetic resonance in medicine · 2025Article
- Added value of multifrequency magnetic resonance elastography in predicting pathological grading of pancreatic neuroendocrine neoplasms.Insights into imaging · 2025Article
- Establishment of multifrequency magnetic resonance elastography for adrenal gland imaging: feasibility and reproducibility for assessing stiffness and fluidity in the healthy adrenal gland.Quantitative imaging in medicine and surgery · 2025Article
- Automated liver and spleen segmentation for MR elastography maps using U-Nets.Scientific reports · 2025Article
- Assessing Intervertebral Disk Tissue Mechanics Using Dual-Actuator Multifrequency Magnetic Resonance Elastography: Case Reports.Case reports in medicine · 2025Article
- Effects of oral contrast agent on the viscoelastic properties of the terminal ileum investigated using magnetic resonance elastography.Quantitative imaging in medicine and surgery · 2024Article
- Free-breathing motion corrected magnetic resonance elastography of the abdomen.Quantitative imaging in medicine and surgery · 2024Article
- Viscoelastic parameters derived from multifrequency MR elastography for depicting hepatic fibrosis and inflammation in chronic viral hepatitis.Insights into imaging · 2024Article
- Semiautomated segmentation of hepatocellular carcinoma tumors with MRI using convolutional neural networks.European radiology · 2023Article
- Feasibility ofQuantitative imaging in medicine and surgery · 2023Article
- Three-dimensional multifrequency magnetic resonance elastography improves preoperative assessment of proliferative hepatocellular carcinoma.Insights into imaging · 2023Article
- Diagnostic comparison of vibration-controlled transient elastography and MRI techniques in overweight and obese patients with NAFLD.Scientific reports · 2022Article
- Tomoelastography based on multifrequency MR elastography predicts liver function reserve in patients with hepatocellular carcinoma: a prospective study.Insights into imaging · 2022Article
- On the relationship between metabolic capacities andFrontiers in bioengineering and biotechnology · 2022Article
- Cerebral tomoelastography based on multifrequency MR elastography in two and three dimensions.Frontiers in bioengineering and biotechnology · 2022Article
- Added Value of Tomoelastography for Characterization of Pancreatic Neuroendocrine Tumor Aggressiveness Based on Stiffness.Cancers · 2021Article
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13 authors.
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Abstract
objectivesTo determine the diagnostic performance, cut-off values, and optimal drive frequency range for staging hepatic fibrosis using tomoelastography by multifrequency MR elastography of the liver and spleen.
methodsThis prospective study consecutively enrolled a total of 61 subjects between June 2014 and April 2017: 45 patients with chronic liver disease and proven stage of fibrosis and 16 healthy volunteers. Tomoelastography was performed at 1.5 T using six drive frequencies from 35 to 60 Hz. Cut-off values and AUC were calculated. Shear wave speed (in m/s) of the liver and spleen was assessed separately and in combination as a surrogate of stiffness.
resultsFor compound multifrequency processing of the liver, cut-off and AUC values by fibrosis stage were as follows: F1, 1.52 m/s and 0.89; F2, 1.55 m/s and 0.94; F3, 1.67 m/s and 0.98; and F4, 1.72 m/s and 0.98. Diagnostic performance of the best single drive frequencies (45 Hz, 55 Hz, 60 Hz) was similar (mean AUC = 0.95, respectively). Combined analysis of the liver and spleen slightly improved performance at 60 Hz in F4 patients (mean AUC = 0.97 vs. 0.95, p = 0.03). Full-field-of-view elastograms displayed not only the liver and spleen but also small anatomical structures including the pancreas and major vessels.
conclusionTomoelastography provides full-field-of-view elastograms with unprecedented detail resolution and excellent diagnostic accuracy for staging hepatic fibrosis. Our analysis of single-frequency tomoelastography suggests that scan time can be further reduced in future studies, making tomoelastography easier to implement in clinical routine. KEY POINTS: • Tomoelastography provides full-field-of-view elastograms of the abdomen with unprecedented detail resolution and excellent diagnostic accuracy for staging hepatic fibrosis. • Diagnostic performance of single-frequency tomoelastography at higher frequencies (45 Hz, 55 Hz, 60 Hz) and compound multifrequency processing are equivalent for staging hepatic fibrosis. • Combined assessment of hepatic and splenic stiffness slightly improves diagnostic performance for staging hepatic fibrosis.
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